Manufacturing of nanochannels with controlled dimensions using protease nanolithography

被引：19
|
作者：
Ionescu, RE [1 ]
Marks, RS [1 ]
Gheber, LA [1 ]
机构：
[1] Ben Gurion Univ Negev, Dept Biotechnol Engn, IL-84105 Beer Sheva, Israel
来源：
NANO LETTERS | 2005年 / 5卷 / 05期
关键词：
D O I：
10.1021/nl0500510
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The feasibility of creating nanometer scale depressions in biological substrates using active enzymes delivered with scanning probe microscopes has been previously demonstrated by us and other groups. Here we present a comprehensive study revealing the dependence of channels dimensions on the parameters of the "writing" process and provide a simple way to precisely control their dimensions. Such nanochannels may be used in nanofluidic biochip applications.
引用
收藏
页码：821 / 827
页数：7
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