BMIM[BF4]: An Efficient Ionic Liquid Medium for the Synthesis of Chromeno[b]pyridines as Potential Anticancer Agents

被引：2

作者：

Kalpana, K. ^{[1
]}

Rani, V. A. ^{[2
]}

Seshadri, S. ^{[3
]}

Kiran, B. Ravi ^{[1
]}

机构：

[1] Gokaraju Rangaraju Inst Engn & Technol, Dept Humanities & Sci Chem, Hyderabad 500090, India

[2] Inst Aeronaut Engn, Dept Chem, Hyderabad 500043, India

[3] Nirma Univ, Inst Sci, Ahmadabad 382470, Gujarat, India

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 57卷 / 09期

关键词：

green synthesis; one-pot reaction; anticancer activity; molecular descriptors prediction; chromeno[4; 3-b]pyridines; DERIVATIVES;

D O I：

10.1134/S1070428021090177

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 2-amino-4-aryl-5-oxochromeno[4,3-b]pyridine-3-carbonitriles have been synthesized with good yields (85-90%) by reacting 4-amino-2H-chromen-2-one, substituted benzaldehydes, and malono-nitrile at 80-85 degrees C for 90-120 min using 1-butyl-3-methylimidazolium tetrafluoroborate as an ionic liquid medium. The synthesized derivatives have been screened for their anticancer potential on SKOV-3 and PC-3 cell lines, and the results were found to be encouraging. In addition, molecular descriptor prediction was performed for the compounds in terms of Lipinski's rule of five; in particular, their topological polar surface areas (TPSA) and lipophilicities (iLogP) were found to be within an acceptable range.

引用

页码：1501 / 1507

页数：7

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