Immunohistochemical detection of a potential molecular therapeutic target for canine hemangiosarcoma

被引：9
|
作者：
Adachi, Mami [1 ]
Hoshino, Yuki [2 ]
Izumi, Yusuke [1 ]
Takagi, Satoshi [2 ]
机构：
[1] Hokkaido Univ, Dept Vet Clin Sci, Lab Adv Vet Med, Sapporo, Hokkaido 0600818, Japan
[2] Hokkaido Univ, Vet Teaching Hosp, Sapporo, Hokkaido 0600818, Japan
来源：
JOURNAL OF VETERINARY MEDICAL SCIENCE | 2016年 / 78卷 / 04期
关键词：
canine hemangiosarcoma dog; immunohistochemistry; MAPK pathway; PI3K/Akt/m-TOR pathway; receptor tyrosine kinase; SPLENIC HEMANGIOSARCOMA; MAMMALIAN TARGET; CELL-LINES; RASH2; MICE; DOGS; PATHWAY; CHEMOTHERAPY; DOXORUBICIN; EXPRESSION; TUMORS;
D O I：
10.1292/jvms.15-0625
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Canine hemangiosarcoma (HSA) is a progressive malignant neoplasm of dogs for which there is currently no effective treatment. A recent study suggested that receptor tyrosine kinases (RTKs), the PI3K/Akt/m-TOR and MAPK pathways are all activated in canine and human HSA. The aim of the present study was to investigate the overexpression of these proteins by immunohistochemistry in canine splenic HSA to identify potential molecular therapeutic targets. A total of 10 splenic HSAs and two normal splenic samples surgically resected from dogs were sectioned and stained with hematoxylin and eosin for histological diagnosis or analyzed using immunohistochemistry. The expression of RTKs, c-kit, VEGFR-2 and PDGFR-2, as well as PI3K/Akt/m-TOR and MEK was higher in canine splenic HSAs compared to normal spleens. These proteins may therefore be potential therapeutic targets in canine splenic HSA.
引用
收藏
页码：649 / 656
页数：8
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