Solid-phase synthesis of a tyrphostin ether library

被引：20

作者：

Guo, GH ^{[1
]}

Arvanitis, EA ^{[1
]}

Pottorf, RS ^{[1
]}

Player, MR ^{[1
]}

机构：

[1] 3 Dimens Pharmaceut Inc, Cranbury, NJ 08512 USA

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2003年 / 5卷 / 04期

关键词：

D O I：

10.1021/cc030003i

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The solid-phase synthesis of a 4500-member (30 x 15 x 10) tyrphostin library is demonstrated utilizing the Irori-directed sorting system. Fmoc-protected PL-Rink resin was used as the solid support. After Fmoc-deprotection, aryl aldehydes were attached to the resin through reductive amination. Acylation of the resulting secondary amines with cyanoacetic acid was followed by a Knoevenagel condensation with phenolic aldehydes. Mitsunobu coupling of primary alcohols to the resin-bound phenols yielded the final library of compounds 1.

引用

页码：408 / 413

页数：6

共 50 条

[21] A new "traceless" solid-phase synthesis strategy: Synthesis of a benzimidazole library
Huang, WL
Scarborough, RM
TETRAHEDRON LETTERS, 1999, 40 (14) : 2665 - 2668
[22] Recent developments oligosaccharide synthesis: Tactics, solid-phase synthesis and library synthesis
Kanemitsu, T
Kanie, O
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 2002, 5 (05) : 339 - 360
[23] Solid-phase synthesis of a focused library of trypanothione reductase inhibitors
De Luca, S
Ulhaq, S
Dixon, MJ
Essex, J
Bradley, M
TETRAHEDRON LETTERS, 2003, 44 (15) : 3195 - 3197
[24] Solid-phase library synthesis of polyynes similar to natural products
Lee, Seonwoo
Lee, Taeho
Lee, Yun Mi
Kim, Deukjoon
Kim, Sanghee
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (44) : 8422 - 8425
[25] Solid-phase synthesis of a biaryl-piperidine library.
Zhu, J
Pottorf, RS
Player, MR
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U89 - U89
[26] REDUCTIVE ALKYLATION ON A SOLID-PHASE - SYNTHESIS OF A PIPERAZINEDIONE COMBINATORIAL LIBRARY
GORDON, DW
STEELE, J
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (01) : 47 - 50
[27] Solid-phase oligosaccharide chemistry and its application to library synthesis
Grathwohl, M
Drinnan, N
Broadhurst, M
West, ML
Meutermans, W
COMBINATORIAL CHEMISTRY, PT B, 2003, 369 : 248 - 267
[28] Solid-phase compound library synthesis in drug design and development
Edwards, PJ
Morrell, AI
CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, 2002, 5 (04) : 594 - 605
[29] Solid-phase synthesis of a library of 2-pyrrolidinone derivatives
Vergnon, AL
Pottorf, RS
Winters, MP
Player, MR
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 227 : U161 - U161
[30] Solid-phase epothilone synthesis used to create analog library
不详
CHEMICAL & ENGINEERING NEWS, 1997, 75 (20) : 33 - 33

← 1 2 3 4 5 →