Cysteine Prevents the Development of Experimental Diabetes Induced by Zinc-Binding Substances

被引：0
|
作者：
Meyramov, G. G. [1 ,3 ]
Kohnert, K-D [1 ,2 ]
Shaybek, A. Zh [1 ,3 ]
Meyramova, D. A. [1 ,3 ]
Kartbayeva, G. T. [3 ]
Tykezhanova, G. M. [3 ]
Starikova, A. E. [3 ]
Kovalenko, O. L. [3 ]
Zhumagalieva, Zh Zh [3 ]
机构：
[1] EA Buketov Karaganda State Univ, Diabetol Res Grp, Karaganda, Kazakhstan
[2] Inst Diabet Gerhardt Katsh, Karlsburg, Germany
[3] EA Buketov Karaganda State Univ, Karaganda, Kazakhstan
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2020年 / 168卷 / 05期
关键词：
beta cells; cysteine; sulfhydryl groups; diabetogenic zinc-binding substances (DZB); 8-para-toluene sulfonamide quinoline (TSQ);
D O I：
10.1007/s10517-020-04765-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In experimental rabbits, cysteine injected intravenously in a dose of 1000 mg/kg temporarily bound zinc in beta cells and prevented the formation of chelate zinc complexes in response to subsequent injection of diabetogenic zinc-binding substances that induce cell destruction. Injection of cysteine to animals was associated with a sharply negative reaction to zinc in beta cells, which attests to blockade of zinc ions. Injection of cysteine few minutes after dithizone and formation of zinc-dithizone complex was followed by displacement of dithizone from the complex and prevented the development of diabetes in most animals. The most plausible mechanism of preventive effect of cysteine is the formation of 2:1 zinc-cysteine complex in beta cells with possible fixation of Zn atom between sulfur atoms from SH groups of two cysteine molecules.
引用
收藏
页码：621 / 626
页数：6
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