Multi-model robust control of depth of hypnosis

被引：23

作者：

Sadati, Nasser ^{[1
]}

Hosseinzadeh, Mehdi ^{[2
]}

Dumont, Guy A. ^{[3
]}

机构：

[1] Sharif Univ Technol, Dept Elect Engn, Tehran 113659363, Iran

[2] Univ Tehran, Coll Engn, Sch Elect & Comp Engn, Tehran 14395515, Iran

[3] Univ British Columbia, Dept Elect & Comp Engn, Vancouver, BC V6T 1Z4, Canada

来源：

BIOMEDICAL SIGNAL PROCESSING AND CONTROL | 2018年 / 40卷

关键词：

Automated drug delivery; Anesthesia; Pharmacokinetic-pharmacodynamic modeling; Depth of hypnosis; Multi-model robust control scheme; CLOSED-LOOP CONTROL; PROPOFOL ANESTHESIA; BISPECTRAL ANALYSIS; INDEX;

D O I：

10.1016/j.bspc.2017.10.003

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This paper presents a multi-model robust control scheme to control the depth of hypnosis during intravenous administration of propofol. The objective of the proposed control scheme is to provide an adequate drug administration regime for propofol to avoid overdosing and underdosing of patients. The proposed scheme is designed to withstand the patient's inherent drug response variability, to achieve good output disturbance and sensor noise rejection, and to attain a good set point response. A comprehensive simulation study of 44 patients is presented to assess the performance of the proposed control scheme. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：443 / 453

页数：11

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