SIRT3 and cancer: Tumor promoter or suppressor?

被引：157
|
作者：
Alhazzazi, Turki Y. [1 ]
Kamarajan, Pachiyappan [1 ]
Verdin, Eric [2 ]
Kapila, Yvonne L. [1 ]
机构：
[1] Univ Michigan, Sch Dent, Dept Periodont & Oral Med, Ann Arbor, MI 48109 USA
[2] Univ Calif San Francisco, Gladstone Inst Virol & Immunol, San Francisco, CA 94158 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2011年 / 1816卷 / 01期
关键词：
Sirtuin-3; SIRT3; Cancer; Tumor promoter; Tumor suppressor; HISTONE DEACETYLASE INHIBITORS; IN-SITU HYBRIDIZATION; BCL-2 FAMILY PROTEINS; FATTY-ACID OXIDATION; CARCINOMA CELL-LINES; CALORIE RESTRICTION; SIRT3-MEDIATED DEACETYLATION; CHROMOSOMAL ORGANIZATION; INSULIN-SECRETION; DOWN-REGULATION;
D O I：
10.1016/j.bbcan.2011.04.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sirtuins (SIRT1-7), the mammalian homologues of the Sir2 gene in yeast, have emerging roles in age-related diseases, such as cardiac hypertrophy, diabetes, obesity, and cancer. However, the role of several sirtuin family members, including SIRT1 and SIRT3, in cancer has been controversial. The aim of this review is to explore and discuss the seemingly dichotomous role of SIRT3 in cancer biology with particular emphasis on its potential role as a tumor promoter and tumor suppressor. This review will also discuss the potential role of SIRT3 as a novel therapeutic target to treat cancer. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：80 / 88
页数：9
相关论文
共 50 条
  • [41] SiRT3 in Cardiac Physiology and Disease
    Koentges, Christoph
    Bode, Christoph
    Bugger, Heiko
    FRONTIERS IN CARDIOVASCULAR MEDICINE, 2016, 3
  • [42] SIRT3 as a Regulator of Hepatic Autophagy
    Cho, Chun-Seok
    Lombard, David B.
    Lee, Jun Hee
    HEPATOLOGY, 2017, 66 (03) : 700 - 702
  • [43] SIRT3 Negatively Regulates TFH-Cell Differentiation in Cancer
    Hou, Yueru
    Cao, Yejin
    He, Ying
    Dong, Lin
    Zhao, Longhao
    Dong, Yingjie
    Niu, Ruiying
    Bi, Yujing
    Liu, Guangwei
    CANCER IMMUNOLOGY RESEARCH, 2024, 12 (07) : 891 - 904
  • [44] SIRT3: a potential target for CHF?
    Liu, Peiqing
    FASEB JOURNAL, 2019, 33
  • [45] SIRT3: Striking at the heart of aging
    Liu, Yufei
    Zhang, Dan
    Chen, Danica
    AGING-US, 2011, 3 (01): : 1 - 2
  • [46] SIRT3 Controls Cancer Metabolic Reprogramming by Regulating ROS and HIF
    Schumacker, Paul T.
    CANCER CELL, 2011, 19 (03) : 299 - 300
  • [47] SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells
    Ozden, Ozkan
    Park, Seong-Hoon
    Wagner, Brett A.
    Song, Ha Yong
    Zhu, Yueming
    Vassilopoulos, Athanassios
    Jung, Barbara
    Buettner, Garry R.
    Gius, David
    FREE RADICAL BIOLOGY AND MEDICINE, 2014, 76 : 163 - 172
  • [48] Ozone and SIRT3: an unexplored paradigm
    Syed, Deeba N.
    Mukhtar, Hasan
    EXPERIMENTAL DERMATOLOGY, 2013, 22 (06) : 396 - 396
  • [49] SIRT3:a potential target for CHF?
    Zhong-bao YUE
    Jia YOU
    Zhuo-ming LI
    Shao-rui CHEN
    Pei-qing LIU
    中国药理学与毒理学杂志, 2018, 32 (04) : 329 - 329
  • [50] SIRT3与肾脏疾病
    韩植芬
    张悦
    生理科学进展, 2021, 52 (05) : 371 - 375
12345