A novel method of using hollow-core photonic crystal fiber as a Raman biosensor

被引：7
|
作者：
Naji, Majid [1 ]
Khetani, Altaf [1 ]
Lagali, Neil [2 ]
Munger, Rejean [2 ]
Anis, Hanan [1 ]
机构：
[1] Univ Ottawa, Sch Informat Technol & Engn, Dept Elect Engn, Ottawa, ON, Canada
[2] Ottawa Civic Hosp, Ottawa Hlth Res Inst, Ottawa, ON, Canada
来源：
NANOSCALE IMAGING, SENSING, AND ACTUATION FOR BIOMEDICAL APPLICATIONS V | 2008年 / 6865卷
关键词：
hollow-core; photonic crystal fiber; Raman spectroscopy; biosensors; non-selective filling;
D O I：
10.1117/12.763158
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
A new method for using a non-selectively filled hollow-core photonic crystal fiber (HC-PCF) as a sensitive Raman spectroscopy platform suitable for biosensing applications is presented. A 1550 HC-PCF was completely filled with ethanol (core and cladding holes). Using a 785nm excitation laser, the Raman spectrum of ethanol in the fiber core was obtained and compared with the equivalent Raman spectrum of an ethanol-filled cuvette. Using a relatively short 9.5cm length of HC-PCF, a Raman signal enhancement factor of 40 over a bulk solution of ethanol was observed under the same excitation conditions. The small sample volume utilized and longer interaction length provides the potential for compact, sensitive, and low-power Raman sensing of biological materials
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页数：8
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