A novel method of using hollow-core photonic crystal fiber as a Raman biosensor

被引：7

作者：

Naji, Majid ^{[1
]}

Khetani, Altaf ^{[1
]}

Lagali, Neil ^{[2
]}

Munger, Rejean ^{[2
]}

Anis, Hanan ^{[1
]}

机构：

[1] Univ Ottawa, Sch Informat Technol & Engn, Dept Elect Engn, Ottawa, ON, Canada

[2] Ottawa Civic Hosp, Ottawa Hlth Res Inst, Ottawa, ON, Canada

来源：

NANOSCALE IMAGING, SENSING, AND ACTUATION FOR BIOMEDICAL APPLICATIONS V | 2008年 / 6865卷

关键词：

hollow-core; photonic crystal fiber; Raman spectroscopy; biosensors; non-selective filling;

D O I：

10.1117/12.763158

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A new method for using a non-selectively filled hollow-core photonic crystal fiber (HC-PCF) as a sensitive Raman spectroscopy platform suitable for biosensing applications is presented. A 1550 HC-PCF was completely filled with ethanol (core and cladding holes). Using a 785nm excitation laser, the Raman spectrum of ethanol in the fiber core was obtained and compared with the equivalent Raman spectrum of an ethanol-filled cuvette. Using a relatively short 9.5cm length of HC-PCF, a Raman signal enhancement factor of 40 over a bulk solution of ethanol was observed under the same excitation conditions. The small sample volume utilized and longer interaction length provides the potential for compact, sensitive, and low-power Raman sensing of biological materials

引用

页数：8

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