A highly stereoselective synthesis of indolyl N-substituted glycines

被引：53
|
作者：
Jiang, B
Yang, CG
Gu, XH
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
[2] Harvard Univ, McLean Hosp, Sch Med, Alcohol & Drug Abuse Res Ctr, Belmont, MA 02478 USA
来源：
TETRAHEDRON LETTERS | 2001年 / 42卷 / 13期
关键词：
indolyl boronic acid; indolylglycine; stereoselectivity;
D O I：
10.1016/S0040-4039(01)00229-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Optically active alpha -indolyl N-substituted glycines were synthesized by reaction of an indolyl boronic acid with glyoxylic acid using chiral methylbenzylamine as the chiral auxiliary with high diastereoselectivity. The absolute configuration of the product was determined by a single-crystal X-ray analysis. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2545 / 2547
页数：3
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