Enzymatic Formation of Oxygen-Containing Heterocycles in Natural Product Biosynthesis

被引：29
|
作者：
Meng, Song [1 ]
Tang, Gong-Li [1 ]
Pan, Hai-Xue [1 ]
机构：
[1] Univ Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China
来源：
CHEMBIOCHEM | 2018年 / 19卷 / 19期
基金：
中国国家自然科学基金;
关键词：
biosynthesis; cyclization; natural products; oxygen heterocycles; oxygenation; GENE-CLUSTER; AFLATOXIN BIOSYNTHESIS; OXIDATIVE CYCLIZATION; CYTOCHROME-P450; MONOOXYGENASE; POLYKETIDE BIOSYNTHESIS; POLYETHER BIOSYNTHESIS; MOLECULAR-CLONING; DIRIGENT PROTEIN; HETEROLOGOUS EXPRESSION; ASPERGILLUS-PARASITICUS;
D O I：
10.1002/cbic.201800225
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Oxygen-containing heterocycles are widely encountered in natural products that display diverse pharmacological properties and have potential benefits to human health. The formation of O-heterocycles catalyzed by different types of enzymes in the biosynthesis of natural products not only contributes to the structural diversity of these compounds, but also enriches our understanding of nature's ability to construct complex molecules. This minireview focuses on the various modes of enzymatic O-heterocyclization identified in natural product biosynthesis and summarizes the possible mechanisms involved in ring closure.
引用
收藏
页码：2002 / 2022
页数：21
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