High Sensitive Voltammetric Levothyroxine Sodium Determination on Renewable Mercury Film Silver Based Electrode

Levothyroxine sodium (LS, L-T-4) is a sodium salt of natural thyroid hormone thyroxine (T-4), commonly used in treatment of hypothyroidism. In this work a new voltammetric method of levothyroxine sodium (LS) determination using renewable mercury film electrode is presented. A linear voltammetric response was obtained for analyte in the concentration range from 0.025 . 10(-6) mol L-1 (1.99 . 10(-5) g L-1) to 4.0 . 10(-6) mol L-1 (3.19 . 10(-3) g L-1), with a detection limit of 1.8 . 10(-8) mol L-1 for preconcentration time of 30 s. Repeatability of method was determined as RSD % for levothyroxine sodium concentration of 0.2 . 10(-6) mol L-1 as 1.4% (n = 9). The proposed method was successfully applied and validated by studying the recovery of levothyroxine sodium in different pharmaceutical products. (C) 2016 The Electrochemical Society. All rights reserved.