Rhodium(III)-Catalyzed Oxidative Annulation of 7-Azaindoles and Alkynes via Double C-H Activation

被引：100

作者：

Li, Shuai-Shuai ^{[1
,2
,3
]}

Wang, Cheng-Qi ^{[3
]}

Lin, Hui ^{[3
]}

Zhang, Xiao-Mei ^{[1
]}

Dong, Lin ^{[3
]}

机构：

[1] Chinese Acad Sci, Chengdu Inst Organ Chem, Key Lab Asymmetr Synth & Chiraltechnol Sichuan Pr, Chengdu 610041, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

[3] Sichuan Univ, West China Sch Pharm, Educ Minist, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 12期

关键词：

ARYLATION; FUNCTIONALIZATION; HYDROARYLATION;

D O I：

10.1021/acs.orglett.5b01228

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rhodium(III)-catalyzed double C-H activation involving N-directed ortho C-H activation and subsequent roll-over C-H activation of the heterocycle ring has been developed to form complex 7-azaindole derivatives in moderate to excellent yields. A broad scope of 7-azaindoles and internal alkynes has been demonstrated in this oxidative annulation reaction.

引用

页码：3018 / 3021

页数：4

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