Homo- and hetero-dinuclear derivatives of aluminium containing Schiff-base ligands: synthesis, characterization and antibacterial activity of mononuclear derivative of aluminium

Reactions of Al(OPri)3 with LH2 =[R'C(NYOH)CHC(R)OH] R=R'=CH3, Y =(CH2)(2) ((LH2)-H-1); R =CH3, R' =C6H5, Y =(CH2)(2) ((LH2)-H-2); R =R' =CH3, Y =(CH2)(3) ((LH2)-H-3); R =CH3, R' =C6H5, Y =(CH2)(3) ((LH2)-H-4), in 1 : 2 molar ratio give mononuclear derivatives of aluminium AlLLH (1a-1d). Equimolar reactions of AlLLH with M(OPri)(3) (M =Al and B) yield homo- and hetero-dinuclear derivatives AlLLM(OPri)(2) (M=Al=2a-2d M=B=3a-3d). Reaction of 2a with (LH2)-H-1 affords (AlLLAlL1)-L-1-Al-1 (4). All these derivatives have been characterized by elemental analysis, molecular weight measurements and plausible structures have been suggested on the basis of IR, NMR [H-1, C-13, Al-27 and B-11] spectral data and FAB-mass studies of 2b and 3b. Schiff base (LH2)-H-1 and its mononuclear derivative with aluminium ((AlLLH)-L-1-H-1) have been screened for their antibacterial activity against Escherischia coli and Bacillus subtilis.