Palladium-Catalyzed Direct Arylation of Heteroarenes with Aryl Mesylates

被引：89
|
作者：
So, Chau Ming [1 ,2 ]
Lau, Chak Po [1 ,2 ]
Kwong, Fuk Yee [1 ,2 ]
机构：
[1] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
[2] Hong Kong Polytech Univ, State Key Lab Chirosci, Kowloon, Hong Kong, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2011年 / 17卷 / 03期
关键词：
aryl mesylates; C-H activation; direct arylation; heterocycles; palladium; CROSS-COUPLING REACTIONS; ADENOSINE RECEPTOR ANTAGONISTS; CARBON-HYDROGEN BONDS; C-H; SUZUKI-MIYAURA; ROOM-TEMPERATURE; ARYLBORONIC ACIDS; PHOSPHINE-FREE; HEPARANASE INHIBITORS; MECHANISTIC INSIGHTS;
D O I：
10.1002/chem.201002354
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Not so challenging after all! The first general examples of the direct arylation of heteroarenes by using challenging aryl mesylates as electrophiles are disclosed. These easy reaction conditions also allow the functionalization of other heterocycles, such as caffeine, triazole and benzathiazole (see scheme). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：761 / 765
页数：5
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