The gateway reflex: breaking through the blood barriers

被引：1
|
作者：
Murakami, Kaoru [1 ]
Tanaka, Yuki [1 ,2 ]
Murakami, Masaaki [1 ,2 ]
机构：
[1] Hokkaido Univ, Inst Genet Med, Div Psychoimmunol, Kita Ku, Nishi 7,Kita 15 Jo, Sapporo, Hokkaido 0600808, Japan
[2] Inst Quantum Life Sci, Grp Quantum Immunol, Inage Ku, 4-9-1 Anagawa, Chiba, Chiba 2638555, Japan
来源：
INTERNATIONAL IMMUNOLOGY | 2021年 / 33卷 / 12期
关键词：
autoreactive CD4(+) T cells; IL-6; amplifier; neuroimmune interaction; neuromodulation; tissue-specific autoimmune diseases; MULTIPLE-SCLEROSIS; INTERLEUKIN-6; FAMILY; IMMUNE CELLS; MECHANISMS; REMISSION; RELAPSE; GP130;
D O I：
10.1093/intimm/dxab064
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We have been studying inflammatory diseases, with a special focus on IL-6, and discovered two concepts related to inflammation development. One is the gateway reflex, which is induced by the activation of specific neural circuits followed by establishing gateways for autoreactive CD4(+) T cells to pass through blood barriers toward the central nervous system (CNS) and retina during tissue-specific inflammatory diseases. We found that the formation of these gateways is dependent on the IL-6 amplifier, which is machinery for enhanced NF-kappa B activation in endothelial cells at specific sites. We have found five gateway reflexes in total. Here, we introduce the gateway reflex and the IL-6 amplifier.
引用
收藏
页码：743 / 748
页数：6
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