Adenovirus vector-mediated gene transfer into stem cells

被引：37

作者：

Kawabata, Kenji ^{[1
]}

Sakurai, Funlinori ^{[1
]}

Koizumi, Naoya ^{[1
]}

Hayakawa, Takao ^{[2
]}

Mizuguchi, Hiroyuki ^{[1
,3
]}

机构：

[1] Natl Inst Biomed Innovat, Lab Gene Transfer & Regulat, Osaka 5670085, Japan

[2] Pharmaceut & Med Devices Agcy, Tokyo 1000013, Japan

[3] Osaka Univ, Grad Sch Pharmaceut Sci, Osaka 5650871, Japan

来源：

MOLECULAR PHARMACEUTICS | 2006年 / 3卷 / 02期

关键词：

adenovirus; stem cell; gene therapy; regenerative medicine; review;

D O I：

10.1021/mp0500925

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Stem cells, including embryonic stem (ES) cells, mesenchymal stem cells (MSCs), and hematopoietic stem cells (HSCs), are defined by their capacity for self-renewal and multilineage differentiation. Efficient gene transfer into stem cells is essential for the basic research in developmental biology and for therapeutic applications in gene-modified regenerative medicine. Adenovirus (Ad) vectors, based on Ad type 5, can efficiently and transiently introduce the exogenous gene into many cell types via the primary receptor, coxsackievirus, and adenovirus receptor (CAR). However, some kinds of stem cells, such as MSCs and HSCs, cannot be efficiently transduced with conventional Ad vectors based on Ad serotype 5 (Ad5), because of the lack of CAR expression. To overcome this problem, fiber-modified Ad vectors and an Ad vector based on another serotype of Ad have been developed. Here, we review the advances in the development of Ad vectors suitable for stem cells and discuss their application in basic biology and clinical medicine.

引用

页码：95 / 103

页数：9

共 50 条

[31] AAV Vector-Mediated Msx1 Gene Transfer Induces Hematopoietic Stem/Progenitor Cells in Skeletal Muscle
Nobuyoshi, Masaharu
Kume, Akihiro
Matsushita, Takashi
Mizukami, Hiroaki
Okada, Takashi
Urabe, Masashi
Ohgoshi, Yuichi
Endo, Takashi
Ozawa, Keiya
MOLECULAR THERAPY, 2006, 13 : S131 - S131
[32] Adenovirus vector-mediated gene transfer into rat retinal neurons and Muller cells in vitro and in vivo (vol 242, pg 93, 1998)
Fukuhara, M
Suzuki, A
Fukuda, Y
Kosaka, J
NEUROSCIENCE LETTERS, 1998, 243 (1-3) : 157 - 157
[33] Baculovirus vector-mediated transfer of NIS gene into colon tumor cells for radionuclide therapy
Hong-Yan Yin
World Journal of Gastroenterology, 2010, 16 (42) : 5367 - 5374
[34] Retroviral vector-mediated transfer of the interferon-α gene in chronic myeloid leukemia cells
Salesse, S
Moreau-Gaudry, F
Pigeonnier-Lagarde, V
Mazurier, F
Chahine, H
Ged, C
de Verneuil, H
Reiffers, J
Mahon, FX
CANCER GENE THERAPY, 1998, 5 (06) : 390 - 400
[35] Lentiviral vector-mediated gene transfer to endotherial cells compared with adenoviral and retroviral vectors
Sakoda, Tsuyoshi
Kasahara, Nori
Kedes, Larry
Ohyanagi, Mitsumasa
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY, 2007, 37 (01): : 1 - 11
[36] Baculovirus vector-mediated transfer of NIS gene into colon tumor cells for radionuclide therapy
Yin, Hong-Yan
Zhou, Xiang
Wu, Hai-Fei
Li, Biao
Zhang, Yi-Fan
WORLD JOURNAL OF GASTROENTEROLOGY, 2010, 16 (42) : 5367 - 5374
[37] Retroviral vector-mediated gene expression in hematopoietic cells
Baum, C
Richters, A
Ostertag, W
CURRENT OPINION IN MOLECULAR THERAPEUTICS, 1999, 1 (05) : 605 - 612
[38] A vitrectomy improves the transfection efficiency of adenoviral vector-mediated gene transfer to Muller cells
Sakamoto, T
Ueno, H
Goto, Y
Oshima, Y
Ishibashi, T
Inomata, H
GENE THERAPY, 1998, 5 (08) : 1088 - 1097
[39] PSEUDOTYPED RETROVIRAL VECTOR-MEDIATED GENE-TRANSFER INTO HUMAN LEUKEMIC-CELLS
BURNS, JC
LOZINSKI, GM
YEE, JK
FRIEDMANN, T
YU, J
YU, AL
PEDIATRIC RESEARCH, 1994, 35 (04) : A158 - A158
[40] OPTIMIZATION OF RETROVIRAL VECTOR-MEDIATED GENE-TRANSFER INTO ENDOTHELIAL-CELLS INVITRO
KAHN, ML
LEE, SW
DICHEK, DA
CIRCULATION RESEARCH, 1992, 71 (06) : 1508 - 1517

← 1 2 3 4 5 →