Antibiotic Mycotoxins from an Endophytic Fusarium acuminatum Isolated from the Medicinal Plant Geum macrophyllum

被引：0
|
作者：
Clark, Trevor N. [1 ]
Carroll, Madison [2 ]
Ellsworth, Katelyn [1 ]
Guerrette, Roxann [3 ,4 ]
Robichaud, Gilles A. [3 ,4 ]
Johnson, John A. [1 ]
Gray, Christopher A. [1 ,2 ]
机构：
[1] Univ New Brunswick, Dept Biol Sci, 100 Tucker Pk Rd, St John, NB E2L 4L5, Canada
[2] Univ New Brunswick, Dept Chem, 30 Dineen Dr, Fredericton, NB E3B 5A3, Canada
[3] Univ Moncton, Dept Chem & Biochem, 18 Antonine Maillet Ave, Moncton, NB E1A 3E9, Canada
[4] Atlantic Canc Res Inst, 35 Providence Ave, Moncton, NB E1C 8X3, Canada
来源：
NATURAL PRODUCT COMMUNICATIONS | 2018年 / 13卷 / 10期
基金：
加拿大自然科学与工程研究理事会;
关键词：
Lateropyrone; Enniatin B; Enniatin B1; Enniatin B4; Endophyte; Geum macrophyllum; Canadian medicinal plant; Fusarium acuminatum; NATURAL-PRODUCTS; FRIES SACC; ENNIATINS; BIOSYNTHESIS; CULTURE;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An extract of the endophytic fungus Fusarium acuminatum (TC2-084) isolated from the Canadian medicinal plant Geum macrophyllum exhibited significant antimycobacterial activity against Mycobacterium tuberculosis H37Ra when fermented in both malt extract and potato dextrose broths. However, significant differences observed in the NMR spectra of the respective extracts led us to further investigate both. Bioassay guided fractionation revealed that lateropyrone was solely responsible for the bioactivity observed when TC2-084 was fermented in malt extract broth, while the antimycobacterial activity of the extract derived from the isolate fermented in potato dextrose broth was augmented by the presence of enniatins B, B1, and B4 in addition to lateropyrone.
引用
收藏
页码：1301 / 1304
页数：4
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