The role of adult hippocampal neurogenesis in brain health and disease

被引：461
|
作者：
Toda, Tomohisa [1 ]
Parylak, Sarah L. [1 ]
Linker, Sara B. [1 ]
Gage, Fred H. [1 ]
机构：
[1] Salk Inst Biol Studies, Lab Genet, 10010 North Torrey Pines Rd, La Jolla, CA 92037 USA
来源：
MOLECULAR PSYCHIATRY | 2019年 / 24卷 / 01期
关键词：
NEURAL STEM-CELLS; GENERATED GRANULE CELLS; ENHANCED SYNAPTIC PLASTICITY; ELEMENT-BINDING PROTEIN; HILAR BASAL DENDRITES; COPY-NUMBER VARIATION; CLASS-I MHC; DENTATE GYRUS; PROGENITOR CELLS; NEWBORN NEURONS;
D O I：
10.1038/s41380-018-0036-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating evidence suggests that adult-born neurons may play distinct physiological roles in hippocampus-dependent functions, such as memory encoding and mood regulation. In addition, several brain diseases, such as neurological diseases and mood disorders, have deleterious effects on adult hippocampal neurogenesis, and some symptoms of those diseases can be partially explained by the dysregulation of adult hippocampal neurogenesis. Here we review a possible link between the physiological functions of adult-born neurons and their roles in pathological conditions.
引用
收藏
页码：67 / 87
页数：21
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