The virulence for gnotobiotic pigs of live attenuated vaccine strains of Salmonella enterica serovars Typhimurium and Enteritidis

被引：22
|
作者：
Barrow, PA [1 ]
Page, K [1 ]
Lovell, MA [1 ]
机构：
[1] AFRC, Inst Anim Hlth, Compton Lab, Newbury RG20 7NN, Berks, England
来源：
VACCINE | 2001年 / 19卷 / 25-26期
关键词：
pigs; vaccine; Salmonella;
D O I：
10.1016/S0264-410X(01)00065-2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Gnotobiotic pigs were inoculated orally with wild-type or defined aroA or. W cr clp vaccine strains of Salmonella enterica serovars Typhimurium and S. Enteritidis. The parental strains were virulent, inducing severe diarrhoea, dehydration and systemic disease. The cya crp mutant was also highly virulent whereas the aroA strains were attenuated. (C) 2001 Elsevier Science Ltd. All rights reserved.
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收藏
页码：3432 / 3436
页数：5
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