A Case of Mixed Medullary and Follicular Cell Carcinoma of the Thyroid

被引：5
|
作者：
Ueki, Ikuko [1 ]
Ando, Takao [1 ]
Haraguchi, Ai [1 ]
Horie, Ichiro [1 ]
Imaizumi, Misa [1 ]
Hayashi, Tomayoshi [2 ]
Uga, Tatsuya [3 ]
Usa, Toshiro [1 ]
Kawakami, Atsushi [1 ]
机构：
[1] Nagasaki Univ, Grad Sch Biomed Sci, Dept Endocrinol & Metab, Nagasaki, Japan
[2] Nagasaki Univ, Grad Sch Biomed Sci, Dept Pathol, Nagasaki, Japan
[3] Nagasaki Univ, Grad Sch Biomed Sci, Dept Surg, Nagasaki, Japan
来源：
INTERNAL MEDICINE | 2011年 / 50卷 / 12期
关键词：
medullary thyroid carcinoma; follicular thyroid cell; papillary thyroid carcinoma; GLAND; TUMOR; COMPONENTS;
D O I：
10.2169/internalmedicine.50.4749
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A medullary thyroid carcinoma is a malignant tumor derived from the C-cells of the thyroid. Despite their distinct embryological origin, medullary thyroid carcinomas are exceptionally accompanied by a tumor derived from the follicular cells; this is defined as mixed medullary and follicular cell carcinoma. There have been controversies regarding the origin of this rare mixed thyroid carcinoma questioning whether or not a mixed carcinoma originates from a common cancer stem cell. We present a case of mixed medullary and follicular cell carcinoma in which two thyroid carcinomas were found intermingled in the thyroid as well as in the metastatic cervical lymph nodes. We examined the tumor by immunostaining with thyroglobulin, calcitonin, and thyroid transcription factor-1, and also reviewed the literature and discuss the origin of this rare mixed thyroid carcinoma.
引用
收藏
页码：1313 / 1316
页数：4
相关论文
共 50 条
  • [41] Mixed medullary and follicular cell carcinoma of the thyroid in a 71-year-old man with history of malignant melanoma
    Maruna, Pavel
    Duskova, Jaroslava
    Limanova, Zdena
    Dvorakova, Sarka
    Vaclavikova, Ellska
    Bendlova, Bela
    MEDICAL SCIENCE MONITOR, 2008, 14 (04): : CS31 - CS36
  • [42] Mixed medullary and follicular cell carcinoma of the thyroid with lymph node metastasis in a 7-year-old child
    Goyal, R
    Nada, R
    Rao, KLN
    Radotra, BD
    PATHOLOGY INTERNATIONAL, 2006, 56 (02) : 84 - 88
  • [43] Mixed Medullary-Papillary Carcinoma of the Thyroid: A Case Report
    Hasney, Christian P.
    Amedee, Ronald G.
    LARYNGOSCOPE, 2010, 120 : S153 - S153
  • [44] Combined “mixed medullary-follicular” and “papillary” carcinoma of the thyroid with lymph node metastasis
    Michio Shimizu
    Mitsuyoshi Hirokawa
    Virginia A. LiVolsi
    Yuji Mizukami
    Tanekazu Harada
    Tomoo Itoh
    Toshiaki Manabe
    Endocrine Pathology, 2000, 11 : 353 - 358
  • [45] MIXED MEDULLARY-FOLLICULAR CARCINOMA OF THE THYROID - IMMUNOHISTOCHEMICAL AND ELECTRON-MICROSCOPIC STUDIES
    OGAWA, H
    KINO, I
    ARAI, T
    ACTA PATHOLOGICA JAPONICA, 1989, 39 (01): : 67 - 72
  • [46] Combined "mixed medullary-follicular" and "papillary" carcinoma of the thyroid with lymph node metastasis
    Shimizu, M
    Hirokawa, M
    LiVolsi, VA
    Mizukami, Y
    Harada, T
    Itoh, T
    Manabe, T
    ENDOCRINE PATHOLOGY, 2000, 11 (04) : 353 - 358
  • [47] RET proto-oncogene mutation in a mixed medullary-follicular thyroid carcinoma
    Orlandi, F
    Chiefari, E
    Caraci, P
    Mussa, A
    Gonzatto, I
    De Giuli, P
    Giuffrida, D
    Angeli, A
    Filetti, S
    JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2001, 24 (01) : 51 - 55
  • [48] CARCINOMA OF THE THYROID WITH A MIXED MEDULLARY AND FOLLICULAR PATTERN - MORPHOLOGIC, IMMUNOHISTOCHEMICAL, AND CLINICAL LABORATORY STUDIES
    HALES, M
    ROSENAU, W
    OKERLUND, MD
    GALANTE, M
    CANCER, 1982, 50 (07) : 1352 - 1359
  • [49] MEDULLARY (C-CELL) CARCINOMA OF THE THYROID WITH FEATURES OF FOLLICULAR OXYPHILIC CELL TUMORS
    HARACH, HR
    BERGHOLM, U
    HISTOPATHOLOGY, 1988, 13 (06) : 645 - 656
  • [50] MEDULLARY CARCINOMA OF THE THYROID-GLAND WITH FOLLICULAR STRUCTURES
    BIERSACK, HJ
    BRIELE, B
    HOTZE, AL
    VOGEL, J
    ONKOLOGIE, 1993, 16 (02): : 121 - 121
12345