Copper-Catalyzed Regio- and Enantioselective Synthesis of Chiral Enol Acetates and β-Substituted Aldehydes

被引：34
|
作者：
Fananas-Mastral, Martin [1 ]
Feringa, Ben L. [1 ]
机构：
[1] Univ Groningen, Stratingh Inst Chem, NL-9747 AG Groningen, Netherlands
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 38期
关键词：
ASYMMETRIC CONJUGATE ADDITION; LIGANDS; KETONES;
D O I：
10.1021/ja105585y
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The in situ transformation of alpha,beta-unsaturated aldehydes into alpha-chloroallylic acetates and subsequent copper-catalyzed regio- and enantioselective (up to 94% ee) allylic alkylation with Grignard reagents provides chiral enol acetates and chiral beta-substituted aldehydes in a one-pot protocol.
引用
收藏
页码：13152 / 13153
页数：2
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