alpha-Lactalbumin is a tryptophan-rich protein fraction. A diet enriched with alpha-lactalbumin increases the ratio of tryptophan to the other large neutral amino acids, which may in turn increase brain serotonin content. In stress-vulnerable individuals, alpha-lactalbumin improved mood and attenuated the cortisol response after experimental stress. The aim of the present study was to investigate the effects of an alpha-lactalbumin-enriched diet on mood and stress response in recovered depressed subjects and healthy controls. Forty-three subjects (twenty-three recovered depressed and twenty healthy subjects) received alpha-lactalbumin and casein (placebo) on separate days, in a double-blind randomised crossover design. On both occasions, subjects underwent a stress test (an unsolvable mental arithmetic task with loud noise). The stress test affected mood in both conditions. Although the alpha-lactalbumin diet led to the expected rises in tryptophan and tryptophan:large neutral amino acids ratio, only minimal effects were found on mood and cortisol response to experimental stress. The results were the same for recovered depressed patients and controls. A 1 d diet enriched with alpha-lactalbumin is not sufficient to prevent a stress-induced mood deterioration or a cortisol response in unmedicated, recovered depressed subjects. Future studies may investigate the effects of longer-term diets or may investigate different samples (e.g. medicated patients).
机构:
Section of Developmental Psychiatry, Department of Psychiatry, University of Cambridge, CambridgeSection of Developmental Psychiatry, Department of Psychiatry, University of Cambridge, Cambridge
Wilkinson P.O.
Goodyer I.M.
论文数: 0引用数: 0
h-index: 0
机构:
Section of Developmental Psychiatry, Department of Psychiatry, University of Cambridge, CambridgeSection of Developmental Psychiatry, Department of Psychiatry, University of Cambridge, Cambridge
机构:
Western Australian Inst Med Res, Ctr Food & Genom Med, Perth, WA, Australia
Shaanxi Normal Univ, Coll Life Sci, Xian, Peoples R ChinaWestern Australian Inst Med Res, Ctr Food & Genom Med, Perth, WA, Australia
Yang, Xingbin
Croft, Kevin D.
论文数: 0引用数: 0
h-index: 0
机构:
Western Australian Inst Med Res, Ctr Food & Genom Med, Perth, WA, AustraliaWestern Australian Inst Med Res, Ctr Food & Genom Med, Perth, WA, Australia
Croft, Kevin D.
Lee, Ya P.
论文数: 0引用数: 0
h-index: 0
机构:
Curtin Univ Technol, Sch Pharm, Perth, WA, AustraliaWestern Australian Inst Med Res, Ctr Food & Genom Med, Perth, WA, Australia
Lee, Ya P.
Mori, Trevor A.
论文数: 0引用数: 0
h-index: 0
机构:Western Australian Inst Med Res, Ctr Food & Genom Med, Perth, WA, Australia
Mori, Trevor A.
Puddey, Ian B.
论文数: 0引用数: 0
h-index: 0
机构:
Western Australian Inst Med Res, Ctr Food & Genom Med, Perth, WA, AustraliaWestern Australian Inst Med Res, Ctr Food & Genom Med, Perth, WA, Australia
Puddey, Ian B.
Sipsas, Sofia
论文数: 0引用数: 0
h-index: 0
机构:
Dept Agr & Food, Perth, WA, AustraliaWestern Australian Inst Med Res, Ctr Food & Genom Med, Perth, WA, Australia
Sipsas, Sofia
Barden, Anne
论文数: 0引用数: 0
h-index: 0
机构:
Western Australian Inst Med Res, Ctr Food & Genom Med, Perth, WA, AustraliaWestern Australian Inst Med Res, Ctr Food & Genom Med, Perth, WA, Australia
Barden, Anne
Swinny, Ewald
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Chem, Perth, WA, AustraliaWestern Australian Inst Med Res, Ctr Food & Genom Med, Perth, WA, Australia
Swinny, Ewald
Hodgson, Jonathan M.
论文数: 0引用数: 0
h-index: 0
机构:
Western Australian Inst Med Res, Ctr Food & Genom Med, Perth, WA, Australia
Univ Western Australia, Sch Med & Pharmacol, Royal Perth Hosp Unit, Perth, WA 6847, AustraliaWestern Australian Inst Med Res, Ctr Food & Genom Med, Perth, WA, Australia