The effects of a diet enriched with α-lactalbumin on mood and cortisol response in unmedicated recovered depressed subjects and controls

被引:44
|
作者
Merens, W
Booij, L
Markus, R
Zitman, FG
Onkenhout, W
Van der Does, AJW [1 ]
机构
[1] Leiden Univ, Dept Psychol, Leiden, Netherlands
[2] Maastricht Univ, Dept Psychol, Maastricht, Netherlands
[3] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands
[4] Leiden Univ, Med Ctr, Dept Pediat, Leiden, Netherlands
关键词
alpha-lactalbumin; depression; serotonin; cortisol;
D O I
10.1079/BJN20051492
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
alpha-Lactalbumin is a tryptophan-rich protein fraction. A diet enriched with alpha-lactalbumin increases the ratio of tryptophan to the other large neutral amino acids, which may in turn increase brain serotonin content. In stress-vulnerable individuals, alpha-lactalbumin improved mood and attenuated the cortisol response after experimental stress. The aim of the present study was to investigate the effects of an alpha-lactalbumin-enriched diet on mood and stress response in recovered depressed subjects and healthy controls. Forty-three subjects (twenty-three recovered depressed and twenty healthy subjects) received alpha-lactalbumin and casein (placebo) on separate days, in a double-blind randomised crossover design. On both occasions, subjects underwent a stress test (an unsolvable mental arithmetic task with loud noise). The stress test affected mood in both conditions. Although the alpha-lactalbumin diet led to the expected rises in tryptophan and tryptophan:large neutral amino acids ratio, only minimal effects were found on mood and cortisol response to experimental stress. The results were the same for recovered depressed patients and controls. A 1 d diet enriched with alpha-lactalbumin is not sufficient to prevent a stress-induced mood deterioration or a cortisol response in unmedicated, recovered depressed subjects. Future studies may investigate the effects of longer-term diets or may investigate different samples (e.g. medicated patients).
引用
收藏
页码:415 / 422
页数:8
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