Current Progresses of Exosomes as Cancer Diagnostic and Prognostic Biomarkers

被引：185
|
作者：
Huang, Tao [1 ]
Deng, Chu-Xia [1 ]
机构：
[1] Univ Macau, Fac Hlth Sci, Macau, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2019年 / 15卷 / 01期
关键词：
exosomes; cancer; biomarkers; therapy; diagnosis; prognosis; CIRCULATING TUMOR-CELLS; LONG NONCODING RNA; BREAST-CANCER; EXTRACELLULAR VESICLES; PANCREATIC-CANCER; PROSTATE-CANCER; SERUM EXOSOMES; PROTEOMIC ANALYSIS; MELANOMA EXOSOMES; COLORECTAL-CANCER;
D O I：
10.7150/ijbs.27796
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cancer related exosomes are nano-size membrane vesicles that play important roles in tumor microenvironment. Emerging evidence indicates that exosomes can load unique cargoes, including proteins and nucleic acids that reflect the condition of tumor. Therefore, exosomes are being used as diagnostic and prognostic biomarkers for various cancers. In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer.
引用
收藏
页码：1 / 11
页数：11
相关论文
共 50 条
  • [21] HIV Neuroinflammation: The Role of Exosomes in Cell Signaling, Prognostic and Diagnostic Biomarkers and Drug Delivery
    Mahajan, Supriya D.
    Ordain, Nigel Smith
    Kutscher, Hilliard
    Karki, Shanta
    Reynolds, Jessica L.
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
  • [22] Isolation and characterization of urine exosomes for using as diagnostic biomarkers in prostate cancer
    Anton Cornejo, A.
    Herraiz Lopez, M.
    Sanchis Bonet, A.
    Recio, J.
    Bajo Chueca, A. M.
    Barrionuevo Gonzalez, M.
    CLINICA CHIMICA ACTA, 2019, 493 : S3 - S3
  • [23] Exosomes as Diagnostic Biomarkers in Cardiovascular Diseases
    Jansen, Felix
    Li, Qian
    EXOSOMES IN CARDIOVASCULAR DISEASES: BIOMARKERS, PATHOLOGICAL AND THERAPEUTIC EFFECTS, 2017, 998 : 61 - 70
  • [24] Current early diagnostic biomarkers of prostate cancer
    Qu, Min
    Ren, Shan-Cheng
    Sun, Yinghao
    ASIAN JOURNAL OF ANDROLOGY, 2014, 16 (04) : 549 - 554
  • [25] Urinary microRNA as diagnostic and prognostic biomarkers for prostate cancer
    Fredsoe, Jacob
    Rasmussen, Anni K.
    Thomsen, Anni R.
    Mouritzen, Peter
    Hoyer, Soren
    Borre, Michael
    Orntoft, Torben F.
    Sorensen, Karina D.
    CANCER RESEARCH, 2017, 77
  • [26] Identification of potential diagnostic and prognostic biomarkers for prostate cancer
    Zhang, Qiang
    Yin, Xiujuan
    Pan, Zhiwei
    Cao, Yingying
    Han, Shaojie
    Gao, Guojun
    Gao, Zhiqin
    Pan, Zhifang
    Feng, Weiguo
    ONCOLOGY LETTERS, 2019, 18 (04) : 4237 - 4245
  • [27] Epigenetic Alterations as Cancer Diagnostic, Prognostic, and Predictive Biomarkers
    Deng, Dajun
    Liu, Zhaojun
    Du, Yantao
    EPIGENETICS AND CANCER, PT B, 2010, 71 : 125 - 176
  • [28] Potential diagnostic, prognostic, and predictive biomarkers of gastric cancer
    Mohammed, Ousman
    Gizaw, Solomon Tebeje
    Degef, Maria
    HEALTH SCIENCE REPORTS, 2024, 7 (07)
  • [29] MicroRNA Profile for Diagnostic and Prognostic Biomarkers in Thyroid Cancer
    Park, Jong-Lyul
    Kim, Seon-Kyu
    Jeon, Sora
    Jung, Chan-Kwon
    Kim, Yong-Sung
    CANCERS, 2021, 13 (04) : 1 - 19
  • [30] MicroRNAs as Diagnostic, Prognostic, and Therapeutic Biomarkers in Prostate Cancer
    Aghdam, Arad Mobasher
    Amiri, Atefeh
    Salarinia, Reza
    Masoudifar, Aria
    Ghasemi, Faezeh
    Mirzaei, Hamed
    CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 2019, 29 (02): : 127 - 139
12345