Imported Human West Nile Virus Lineage 2 Infection in Spain: Neurological and Gastrointestinal Complications

被引：5

作者：

Velasco, Maria ^{[1
]}

Sanchez-Seco, Maria Paz ^{[2
]}

Campelo, Carolina ^{[1
]}

de Ory, Fernando ^{[2
,3
]}

Martin, Oriol ^{[1
]}

Herrero, Laura ^{[2
]}

Beliz, Octavio J. Salmeron ^{[1
]}

Minguito, Teodora ^{[2
]}

Campos, Ma Carmen ^{[1
]}

Molero, Francisca ^{[2
]}

Algora, Alejandro ^{[1
]}

Vazquez, Ana ^{[2
,3
]}

机构：

[1] Hosp Univ Fdn Alcorcon, Madrid 28922, Spain

[2] Inst Salud Carlos III, Ctr Nacl Microbiol, Madrid 28220, Spain

[3] Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid 28029, Spain

来源：

VIRUSES-BASEL | 2020年 / 12卷 / 02期

关键词：

West Nile virus lineage 2; human; Spain; neurological symptoms; digestive complications; MOSQUITOS; FEVER;

D O I：

10.3390/v12020156

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report the first human case of West Nile virus (WNV) lineage 2 infection imported to Spain by a traveler returning from Romania. Serum, cerebrospinal fluid and urine samples were analyzed and West Nile virus infection was identified by PCR and serological tests. The patient developed fever, diarrhea and neurological symptoms, accompanied by mild pancreatitis, described previously in very few cases as a complication of WNV infection and by alithiasic cholecystitis. Viral RNA was detected in urine until 30 days after the onset of symptoms and neutralizing antibodies were detected at very low titers. The phylogenetic analysis in a fragment of the NS5 gene of the virus showed a homology with sequences from WNV lineage 2 belonging to the monophyletic Central/Southern European group.

引用

页数：7

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