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Division of Life Science, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, 7-15-4-1 Maeda, Teine, Sapporo,Hokkaido,006-8585, Japan Division of Life Science, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, 7-15-4-1 Maeda, Teine, Sapporo,Hokkaido,006-8585, Japan