Na+/K+-ATPase Activation by cAMP in the Midgut of Lutzomyia longipalpis (Lutz & Neiva, 1912; Diptera: Psychodidae)

被引：2

作者：

Nepomuceno, Denise Barguil ^{[1
]}

DAvila Pessoa, Grasielle Caldas ^{[1
]}

Araujo, Ricardo Nascimento ^{[1
]}

Koerich, Leonardo Barbosa ^{[1
]}

Viana Sant'Anna, Mauricio Roberto ^{[1
]}

Pereira, Marcos Horacio ^{[1
]}

Gontijo, Nelder Figueiredo ^{[1
]}

机构：

[1] Univ Fed Minas Gerais UFMG, Dept Parasitol ICB, Lab Fisiol Insetos Hematofagos, Belo Horizonte, MG, Brazil

来源：

JOURNAL OF INSECT SCIENCE | 2022年 / 22卷 / 02期

关键词：

sandfly; Na+; K+-ATPase; cAMP; midgut; pH; PH CONTROL; V-ATPASE; MECHANISMS; H+; TRANSPORTERS; PHYSIOLOGY; MOSQUITO; FAMILY; K+;

D O I：

10.1093/jisesa/ieac008

中图分类号：

Q96 [昆虫学];

学科分类号：

摘要：

Lutzomyia longipalpis (Lutz & Neiva, 1912) females have been intensively studied regarding the regulation of midgut pH. The mechanisms involved in pH regulation are complex, and some aspects remain to be clarified. Here, we investigated the role of the Na+/K+-ATPase pump as an electrochemical potential generator and its modulation by the second messenger cAMP in the midgut of female L. longipalpis. Our results suggest that not only may Na+/K+-ATPase be the main generator of an electrochemical potential across membranes in the midgut of female L. longipalpis, but also its activity is positively regulated by cAMP. cAMP-mediated Na+/K+-ATPase pump activity might be necessary to maintain the transport of the nutrients produced during blood digestion.

引用

页数：4

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