A mixture of extracts of black and green teas and mulberry leaf did not reduce weight gain in rats fed a high-fat diet

被引:0
|
作者
Fallon, Elizabeth [1 ]
Zhong, Litao [2 ]
Furne, Julie K. [1 ]
Levitt, Michael D. [1 ]
机构
[1] Minneapolis Vet Affairs Med Ctr, Res Serv 151, Minneapolis, MN 55417 USA
[2] NatureGen Inc, San Diego, CA USA
关键词
D O I
暂无
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Tea extracts are used in many over-the-counter preparations claiming to promote weight loss. The rationale for this usage includes reports that green tea extract increases thermogenesis, and extracts of green and black tea and mulberry leaf inhibit the digestion/absorption of carbohydrate and fat. The investigators in this study tested the potential of increasing doses of a mixture of three extracts (50-percent black tea, 20-percent green tea, and 30-percent mulberry) to induce weight loss, steatorrhea, and blood lipid alterations in rats ingesting a high-fat diet, ad lib. The mixture was incorporated into chow in quantities of 0.5-, 3.0-, and 6.0 percent by weight; a control group received only chow. Food intake and weight were monitored daily, and quantitative fecal fat measurements were obtained weekly for four weeks. The 3.0- and 6.0-percent chows significantly increased fecal fat excretion to 15 percent of dietary fat intake (controls: 5%); however, no significant reduction in weight gain was observed. After four weeks of treatment, the 3.0- and 6.0-percent dosages were associated with significant reductions in serum triglycerides and increases in high density lipoprotein (HDL) cholesterol. However, these chow concentrations were associated with significant increases in serum ALT, and the 6.0-percent chow markedly increased serum alkaline phosphatase. This study does not provide support for the utility of this combination of black tea, green tea, and mulberry extracts in weight-loss regimens and indicates that high doses of this extract combination may be hepatotoxic.
引用
收藏
页码:43 / 49
页数:7
相关论文
共 50 条
  • [31] WEIGHT CYCLING INDUCED BY AD-LIB AND RESTRICTED FEEDING OF A HIGH-FAT DIET DID NOT ENHANCE RATE OF WEIGHT-GAIN IN RATS
    LU, HQ
    BUISON, A
    JEN, KLC
    FASEB JOURNAL, 1994, 8 (04): : A170 - A170
  • [32] Effective Suppression of Adipose Tissue Weight Gain in High-fat Diet-fed Mice by 'Benifuuki' Green Tea Consumption
    Inagaki, Hiroyuki
    Sugitani, Masanori
    Setoguchi, Yuko
    Ito, Ryouichi
    Oritani, Yukihiro
    Nishimura, Eisaku
    Sato, Susumu
    Kato, Masatoshi
    Sai, Masahiko
    Maeda-Yamamoto, Mari
    Kamei, Masanori
    JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI, 2009, 56 (07): : 403 - 411
  • [33] Anti-obesity Effects of Some Plant Extracts in Rats Fed with High-Fat Diet
    Al-Azhary, Diaa B.
    Amin, Hanan M.
    Kotb, Eman M.
    NATURAL PRODUCTS JOURNAL, 2022, 12 (04):
  • [34] Ethanol extract of Liuwei Dihuang reduces weight gain and visceral fat in obese-prone CD rats fed a high-fat diet
    Nair, Sandhya V. G.
    Zhang, Junzeng
    Wang, Yanwen
    EXPERIMENTAL BIOLOGY AND MEDICINE, 2014, 239 (05) : 552 - 558
  • [35] Etoricoxib treatment prevented body weight gain and ameliorated oxidative stress in the liver of high-fat diet-fed rats
    Kabir, Fariha
    Nahar, Kamrun
    Rahman, Md Mizanur
    Mamun, Fariha
    Lasker, Shoumen
    Khan, Ferdous
    Yasmin, Tahmina
    Akter, Khondker Ayesha
    Subhan, Nusrat
    Alam, Md Ashraful
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2021, 394 (01) : 33 - 47
  • [36] Rosemary (Rosmarinus officinalis L.) Leaf Extract Limits Weight Gain and Liver Steatosis in Mice Fed a High-Fat Diet
    Harach, Taoufiq
    Aprikian, Olivier
    Monnard, Irina
    Moulin, Julie
    Membrez, Mathieu
    Beolor, Jean-Claude
    Raab, Thomas
    Mace, Katherine
    Darimont, Christian
    PLANTA MEDICA, 2010, 76 (06) : 566 - 571
  • [37] Plant-Based Flours Reduce Body Weight and Adiposity in High-Fat Fed Rats
    Martinez, Taylor
    Duca, Frank
    Weninger, Savanna N.
    Meyer, Rachel
    Lane, Adelina I. L.
    DIABETES, 2020, 69
  • [38] Anti-HMGB1 antibody reduces weight gain in mice fed a high-fat diet
    Montes, V. N.
    Subramanian, S.
    Goodspeed, L.
    Wang, S. A.
    Omer, M.
    Bobik, A.
    Teshigawara, K.
    Nishibori, M.
    Chait, A.
    NUTRITION & DIABETES, 2015, 5 : e161 - e161
  • [39] Anti-HMGB1 antibody reduces weight gain in mice fed a high-fat diet
    V N Montes
    S Subramanian
    L Goodspeed
    S A Wang
    M Omer
    A Bobik
    K Teshigawara
    M Nishibori
    A Chait
    Nutrition & Diabetes, 2015, 5 : e161 - e161
  • [40] Repeated allopregnanolone exposure induces weight gain in schedule fed rats on high fat diet
    Holmberg, E.
    Johansson, M.
    Backstrom, T.
    Lofgren, M.
    Haage, D.
    PHYSIOLOGY & BEHAVIOR, 2015, 140 : 1 - 7