Revised Definitions of Tuberculosis Resistance and Treatment Outcomes, France, 2006-2019

被引：8
|
作者：
Kherabi, Yousra [1 ]
Frechet-Jachym, Mathilde [3 ]
Rioux, Christophe [1 ,4 ]
Yazdanpanah, Yazdan [1 ,2 ,4 ,5 ,6 ]
Mechai, Frederic [7 ,8 ]
Pourcher, Valerie [9 ]
Robert, Jerome [2 ,10 ]
Guglielmetti, Lorenzo [2 ,10 ]
机构：
[1] Hop Bichat Claude Bernard, Assistance Publ Hop Paris, Paris, France
[2] Sorbonne Univ, INSERM, U1135, Paris, France
[3] Ctr Hosp Bligny, Briis Sous Forges, France
[4] Assistance Publ Hop Paris, Paris, France
[5] Univ Paris, INSERM, IAME, Paris, France
[6] Univ Paris Diderot, Paris, France
[7] Hop Avicenne, Assistance Publ Hop Paris, Paris, France
[8] Hop Avicenne, Bobigny, France
[9] Hop La Pitie Salpetriere, Assistance Publ Hop Paris, Paris, France
[10] Sorbonne Univ, Hop Pitie Salpetriere, Assistance Publ Hop Paris, Paris, France
来源：
EMERGING INFECTIOUS DISEASES | 2022年 / 28卷 / 09期
关键词：
CULTURE CONVERSION; XDR-TB; FLUOROQUINOLONES; TOLERABILITY; SAFETY; IMPACT;
D O I：
10.3201/eid2809.220458
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Definitions of resistance in multidrug-resistant tuberculosis (MDR TB) and extensively drug-resistant tuberculosis (XDR TB) have been updated. Pre-XDR TB, defined as MDR TB with additional resistance to fluoroquinolones, and XDR TB, with additional resistance to bedaquiline or linezolid, are frequently associated with treatment failure and toxicity. We retrospectively determined the effects of pre-XDR/XDR TB resistance on outcomes and safety of MDR TB treatment in France. The study included 298 patients treated for MDR TB at 3 reference centers during 2006-2019. Of those, 205 (68.8%) cases were fluoroquinolone-susceptible MDR TB and 93 (31.2%) were preXDR/XDR TB. Compared with fluoroquinolone-susceptible MDR TB, pre-XDR/XDR TB was associated with more cavitary lung lesions and bilateral disease and required longer treatment. Overall, 202 patients (67.8%) had favorable treatment outcomes, with no significant difference between pre-XDR/XDR TB (67.7%) and fluoroquinolone-susceptible MDR TB (67.8%; p = 0.99). Pre-XDR/XDR TB was not associated with higher risk for serious adverse events.
引用
收藏
页码：1796 / 1804
页数：9
相关论文
共 50 条
  • [41] Tuberculosis drug resistance and treatment outcomes under DOTS settings in large cities in the Philippines
    Ohkado, A
    Aguiman, L
    Adlawan, S
    Baring, E
    Quirante, O
    Suchi, M
    Endo, S
    Fujiki, A
    Mori, T
    INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2006, 10 (03) : 283 - 289
  • [42] Treatment Outcomes and Survival Based on Drug Resistance Patterns in Multidrug-resistant Tuberculosis
    Kim, Doh Hyung
    Kim, Hee Jin
    Park, Seung-Kyu
    Kong, Suck-Jun
    Kim, Young Sam
    Kim, Tae-Hyung
    Kim, Eun Kyung
    Lee, Ki Man
    Lee, Sung-Soon
    Park, Jae Seuk
    Koh, Won-Jung
    Lee, Chang-Hoon
    Shim, Tae Sun
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2010, 182 (01) : 113 - 119
  • [43] Development of acquired drug resistance in recurrent tuberculosis patients with various previous treatment outcomes
    Yoshiyama, T
    Yanai, H
    Rhiengtong, D
    Palittapongarnpim, P
    Nampaisan, O
    Supawitkul, S
    Uthaivorawit, W
    Mori, T
    INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2004, 8 (01) : 31 - 38
  • [44] Tuberculosis services and treatment outcomes in private and public health care facilities in Thailand, 2004-2006
    Chengsorn, N.
    Bloss, E.
    Anekvorapong, R.
    Anuwatnonthakate, A.
    Wattanaamornkiat, W.
    Komsakorn, S.
    Moolphate, S.
    Limsomboon, P.
    Kaewsa-ard, S.
    Nateniyom, S.
    Kanphukiew, A.
    Varma, J. K.
    INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2009, 13 (07) : 888 - 894
  • [45] Tuberculosis treatment outcomes of notified cases: trends and determinants of potential unfavourable outcome, France, 2008 to 2014
    Guthmann, Jean-Paul
    Leon, Lucie
    Antoine, Delphine
    Levy-Bruhl, Daniel
    EUROSURVEILLANCE, 2020, 25 (04) : 17 - 27
  • [46] Treatment outcomes of tuberculosis patients detected by active case finding under the Revised National Tuberculosis Control Programme during 2018 in Haridwar district of Uttarakhand
    Singh, Mahendra
    Bahurupi, Yogesh
    Sharma, Abhishek
    Kishore, Surekha
    Aggarwal, Pradeep
    Jain, Bhavna
    Bhadoria, Ajeet Singh
    Reddy, Navuluri Kranthi Kumar
    JOURNAL OF FAMILY MEDICINE AND PRIMARY CARE, 2020, 9 (10) : 5132 - 5135
  • [47] Factors associated with unfavourable treatment outcomes in people with HIV-associated tuberculosis in Armenia, 2015 to 2019
    Gevorgyan, Lilit
    Grigoryan, Ruzanna
    Dumchev, Kostyantyn
    Akopyan, Kristina
    Khachatryan, Anush
    Kabasakalyan, Eduard
    Grigoryan, Trdat
    Safaryan, Marina
    Avagyan, Vardan
    Hasanova, Sayohat
    Matteelli, Alberto
    MONALDI ARCHIVES FOR CHEST DISEASE, 2021, 91 (01)
  • [48] The effect size of type 2 diabetes mellitus on tuberculosis drug resistance and adverse treatment outcomes
    Monserrat Perez-Navarro, Lucia
    Restrepo, Blanca I.
    Javier Fuentes-Dominguez, Francisco
    Duggirala, Ravindranath
    Morales-Romero, Jaime
    Carlos Lopez-Alvarenga, Juan
    Comas, Inaki
    Zenteno-Cuevas, Roberto
    TUBERCULOSIS, 2017, 103 : 83 - 91
  • [49] The effect of internal displacement due to armed conflict on tuberculosis treatment outcomes in northwest Syria, 2019-2020
    Daif, Abdulselam
    Glazik, Rosanna
    Checchi, Francesco
    Khan, Palwasha
    JOURNAL OF MIGRATION AND HEALTH, 2023, 8
  • [50] Development and validation of a prediction model for unsuccessful treatment outcomes in patients with multi-drug resistance tuberculosis
    Ma, J-B
    Zeng, L-C
    Ren, F.
    Dang, L-Y
    Luo, H.
    Wu, Y-Q
    Yang, X-J
    Li, R.
    Yang, H.
    Xu, Y.
    BMC INFECTIOUS DISEASES, 2023, 23 (01)
12345