Anti-hepatotoxic activity of cichotyboside, a sesquiterpene glycoside from the seeds of Cichorium intybus

被引:29
|
作者
Ahmed, Bahar [1 ]
Khan, Shamshir [1 ]
Masood, Mubashir H. [1 ]
Siddique, Anwarul H. [1 ]
机构
[1] Hamdard Univ, Fac Pharm, Dept Pharmaceut Chem, New Delhi 110062, India
关键词
anti-hepatotoxic activity; carbon tetrachloride; Cichorium intybus; silymarin;
D O I
10.1080/10286020701590764
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The seeds of Cichorium intybus L. (Asteraceae) afforded a new guaianolide sesquiterpene glycoside, cichotyboside, which was characterized as 2, 6, 7, 15-tetrahydroxy-1 (10), 4 (5)-diene-guaian-9, 12-olide-7-O--caffoyl-15-O--D-glucoside (1) by means of spectral methods. Cichotyboside (1) exhibited a significant anti-hepatotoxic activity against CCl4 induced toxicity in Wistar rats, wherein it reduced the elevated levels of liver enzymes such as serum glutamate oxaloacetate transaminase (SGOT) by 52 units/ml; SGPT 38 units/ml; ALKP 24.97 units/ml and 7.54g/dl, 5.48g/dl increase in total protein and albumin, respectively. It was observed that cichotyboside (1) decreased the level of ALKP comparable with that of standard drug silymarin, exhibiting an 88% decrease in comparison to silymarin (92%) and increased the level of total albumin 85% in comparison to silymarin (89%) against intoxicated control. Whereas, the levels of SGOT and SGPT were also decreased considerably in comparison to standard and intoxicated control.
引用
收藏
页码:218 / 223
页数:6
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