Adjuvant action of Escherichia coli enterotoxin for delayed-type hypersensitivity to Oka vaccine virus on pernasal co-administration in mice

被引：6
|
作者：
Sasaki, K
Asano, Y
Honma, Y
Kamiya, N
Handa, T
Ichinose, Y
Yokochi, T
Shiraki, K
Tsuji, T [1 ]
机构：
[1] Fujita Hlth Univ, Sch Med, Dept Microbiol, Toyoake, Aichi 4701192, Japan
[2] Fujita Hlth Univ, Sch Med, Dept Pediat, Toyoake, Aichi 4701192, Japan
[3] Nagasaki Univ, Inst Trop Med, Dept Bacteriol, Nagasaki 852, Japan
[4] Aichi Med Univ, Dept Microbiol, Nagakute, Aichi 48011, Japan
[5] Toyama Med & Pharmaceut Univ, Dept Virol, Toyama 93001, Japan
来源：
VACCINE | 2000年 / 19卷 / 7-8期
关键词：
entertoxigenic Escherichia coli; heat-labile enterotoxin; mucosal adjuvant; cellular immunity; VZV;
D O I：
10.1016/S0264-410X(00)00220-6
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The usefulness of a mutant of Escherichia coli enterotoxin for the induction of cellular immunity to varicella-zoster virus as a mucosal adjuvant is assessed in mice. When a commercially available live varicella vaccine (the Oka strain) and toxin were once administered simultaneously via the nasal route, delayed-type hypersensitivity to Oka vaccine virus was significantly induced and detected by footpad test in mice. Moreover, when spleen cells from mice immunized with the vaccine and toxin were re-stimulated with live vaccine in vitro, they showed more thymidine uptake and produced more IL-2 than those from mice immunized with the vaccine alone. These results suggest that mutant enterotoxin has adjuvant action to induce a specific delayed-type hypersensitivity to Oka vaccine virus on nasal co-administration with live vaccine virus. (C) 2000 Elsevier Science Ltd. All rights reserved.
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页码：931 / 936
页数：6
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