A practical enzymatic method for preparation of (S)-ketoprofen with a crude Candida rugosa lipase

被引：12

作者：

Wu, HY ^{[1
]}

Xu, JH ^{[1
]}

Liu, YY ^{[1
]}

机构：

[1] E China Univ Sci & Technol, Lab Appl Biocatalysis, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2001年 / 31卷 / 22期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1081/SCC-100106210

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and practical method for the preparation of (S)-Ketoprofen (2-(3-benzoylphenyl) propionic acid) has been developed through the hydrolysis of its chloroethyl ester catalyzed by a cheap and commercially available crude Candida rugosa lipase preparation under an extremely acidic condition, pH 2.5, and in the presence of Tween-80. As the reaction was carried out in a shake flask with baffles, the degree of hydrolysis was enhanced from 31.5% to 42.2%. A needle-like crystalline of (S)-Ketoprofen was obtained with 95.7% e.e. after simple separation and purification.

引用

页码：3491 / 3496

页数：6

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