The role of E-proteins in B- and T-lymphocyte development

被引：75
|
作者：
Bain, G [1 ]
Murre, C [1 ]
机构：
[1] Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA
来源：
SEMINARS IN IMMUNOLOGY | 1998年 / 10卷 / 02期
关键词：
E proteins; lymphoid development; transcription factors;
D O I：
10.1006/smim.1998.0116
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Development of lymphocytes from hematopoietic stem cells is controlled, in part, by the activity of transcriptional regulatory proteins. In particular, one class of helix-loop-helix proteins, termed E-proteins, have been implicated in the regulation of gene expression during B-cell development. Recent analysis of gene-targeted mice has allowed a direct assessment of the functional roles of several E-protein family members in hematopoiesis. In this review we describe the defects in B- and T-lymphocyte development in mice carrying targeted mutations in the E-protein genes and discuss our current understanding of the rob of these proteins in lymphoid development.
引用
收藏
页码：143 / 153
页数：11
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