Development of cellular magnesium nano-analysis in treatment of clinical magnesium deficiency

A novel technique, using energy dispersive X-ray microanalysis (EXA(tm)), for noninvasive intracellular (i.c.) measurement of magnesium [Mg2+](i) has now been accomplished and proven to be a valuable tool in multiple aspects of normal as well as pathological magnesium metabolism. Since only 1% of total body M2+ is found status with in the intravascular space, serum levels of Mg2+ give little information about a patient's overall Mg2+ respect to this essential mineral. Using the EXA(tm) analysis it has shown been determined that Ma(2+) levels are significantly reduced in many physiological states which may lead to serious pathological conditions [15]. Description of the methodology and examples of data as well as potential applications will focus on intracellular (i.c.) [Mg2+](i) determinations obtained in cells from subjects with cardiovascular disease (CVD) syndromes related to Mg2+ deficiency. Examples of the application of EXA(tm) evaluation include examination of intracellular magnesium and other minerals in a wide spectrum of conditions which include cardiovascular conditions, arrhythmias, heart failure, myocardial infarction. and bypass surgery. Standardization of control values were performed at NASA [12].