Two homosecoiridoids from the flower buds of Lonicera japonica

被引：20

作者：

Song, Wei-Xia ^{[1
,2
]}

Guo, Qing-Lan ^{[1
,2
]}

Yang, Yong-Chun ^{[1
,2
]}

Shi, Jian-Gong ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2015年 / 26卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Lonicera japonica; Homosecoiridoids; Loniaceticiridoside; Lonimalondialiridoside; Anti-inflammatory activity; SECOIRIDOID GLUCOSIDES; TRITERPENOID SAPONINS; COUPLED SECOIRIDOIDS; EUPHORBIA-MICRACTINA; GLYCOSIDES; CONSTITUENTS; SKELETON;

D O I：

10.1016/j.cclet.2014.11.035

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two new homosecoiridoids, named loniaceticiridoside (1) and lonimalondialiridoside (2), were isolated from an aqueous extract of the flower buds of Lonicera japonica. Their structures including the absolute configuration were determined by extensive spectroscopic studies, especially by 2D NMR and CD data analysis. A proposed biosynthetic pathway and preliminary investigations of the biological activity of compounds 1 and 2 are also discussed. (C) 2014 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：517 / 521

页数：5

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