The role of secretory IgA and complement in IgA nephropathy

被引：62
|
作者：
Oortwijn, Beatrijs D. [1 ]
Eijgenroom, On-Willem [1 ]
Rastoldi, Maria-Pia [2 ]
Roos, Anja [1 ,3 ]
Doha, Mohamed R. [1 ]
van Kooten, Cees [1 ]
机构：
[1] Leiden Univ, Med Ctr, Dept Nephrol, NL-2333 ZA Leiden, Netherlands
[2] San Carlos Borromeo Hosp, Renal Immunopathol Lab, Milan, Italy
[3] Leiden Univ, Med Ctr, Dept Clin Chem, Leiden, Netherlands
来源：
SEMINARS IN NEPHROLOGY | 2008年 / 28卷 / 01期
关键词：
secretory IgA; complement activation; IgA nephropathy; mannose binding lectin; antigen-specific IgA;
D O I：
10.1016/j.semnephrol.2007.10.007
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
IgA nephropathy (IgAN) is characterized by glomerular deposition of IgA, often together with complement components. This deposited IgA is mainly polymeric in nature. Although early studies suggested a role for local complement activation in the development of glomerular injury in IgAN, recent attention has focused on the involvement of the lectin pathway of complement activation in the progression of renal disease in IgAN. In addition, we have found that glomerular secretory IgA deposition may be one of the initiators of local complement activation in the kidney. In the present review we discuss recent developments in this area and provide a model of how mucosal immunity and renal inflammation may be interconnected. © 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：58 / 65
页数：8
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