Development of Chimeric Antigen Receptor-Expressing iPSC-Derived Macrophages with Improved Anti-Tumor Activity

被引：3
|
作者：
Pouyanfard, Somayeh [1 ]
Fierro, Manuel [1 ]
Skaufman, Dan [1 ]
机构：
[1] Univ Calif San Diego, Div Regenerat Med, Dept Med, La Jolla, CA USA
来源：
BLOOD | 2021年 / 138卷
关键词：
D O I：
10.1182/blood-2021-148687
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
1693
引用
收藏
页数：3
相关论文
共 50 条
  • [1] Targeted Genomic Insertion of Cars in iPSC-Derived Macrophages Leads to Improved Expression and Anti-Tumor Activity
    Kong, Yuelin
    Fierro, Manuel
    Pouyanfard, Somayeh
    Kaufman, Dan S.
    BLOOD, 2022, 140 : 7390 - 7391
  • [2] Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity
    Li, Ye
    Hermanson, David L.
    Moriarity, Branden S.
    Kaufman, Dan S.
    CELL STEM CELL, 2018, 23 (02) : 181 - +
  • [3] Enhancing the anti-tumor efficacy of chimeric antigen receptor-expressing T cells with naturally occuring plant stilbenes
    Soles, Andrea
    Richardson, Elle
    Barber, Amorette
    FASEB JOURNAL, 2019, 33
  • [4] IPSC-DERIVED NK CELLS MEDIATE ROBUST ANTI-TUMOR ACTIVITY AGAINST GLIOBLASTOMA
    Miller, Jeffrey
    Cichocki, Frank
    Ning, Jianfang
    Bjordahl, Ryan
    Davis, Zachary
    Tuininga, Katie
    Wang, Hongbo
    Rogers, Paul
    Ge, Moyar
    Lee, Tom
    Valamehr, Bob
    Chen, Clark
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 : A93 - A94
  • [5] Blockade of protein kinase A (PKA) localization augments the trafficking and anti-tumor efficacy of adoptively transferred chimeric antigen receptor-expressing T cells
    Newick, Kheng
    O'Brien, Shaun
    Sun, Jing
    Kapoor, Veena
    Maceyko, Steve
    Lo, Albert
    Pure, Ellen
    Moon, Ed K.
    Albelda, Steven M.
    CANCER RESEARCH, 2016, 76
  • [6] Design and development of therapies using chimeric antigen receptor-expressing T cells
    Dotti, Gianpietro
    Gottschalk, Stephen
    Savoldo, Barbara
    Brenner, Malcolm K.
    IMMUNOLOGICAL REVIEWS, 2014, 257 (01) : 107 - 126
  • [7] Dual-antigen targeted iPSC-derived chimeric antigen receptor-T cell therapy for refractory lymphoma
    Harada, Sakiko
    Ando, Miki
    Ando, Jun
    Ishii, Midori
    Yamaguchi, Tomoyuki
    Yamazaki, Satoshi
    Toyota, Tokuko
    Ohara, Kazuo
    Ohtaka, Manami
    Nakanishi, Mahito
    Shin, Chansu
    Ota, Yasunori
    Nakashima, Kazutaka
    Ohshima, Koichi
    Imai, Chihaya
    Nakazawa, Yozo
    Nakauchi, Hiromitsu
    Komatsu, Norio
    MOLECULAR THERAPY, 2022, 30 (02) : 534 - 549
  • [8] Anti-tumor activity of human T cells expressing the CC49-ζ chimeric immune receptor
    McGuinness, RP
    Ge, Y
    Patel, SD
    Kashmiri, SVS
    Lee, HS
    Hand, PH
    Schlom, J
    Finer, MH
    McArthur, JG
    HUMAN GENE THERAPY, 1999, 10 (02) : 165 - 173
  • [9] Anti-tumor efficacy of chimeric NKG2D receptor-expressing T cells requires the induction of host immune responses
    Barber, Amorette
    Rynda, Agnieszka
    Zhang, Tong
    Sentman, Charles
    CANCER RESEARCH, 2009, 69
  • [10] Functional Chimeric Antigen Receptor-Expressing Natural Killer Cells Derived From Human Pluripotent Stem Cells
    Hermanson, David L.
    Ni, Zhenya
    Knorr, David A.
    Bendzick, Laura
    Pribyl, Lee J.
    Geller, Melissa
    Kaufman, Dan S.
    BLOOD, 2013, 122 (21)
12345