IPSC-DERIVED NK CELLS MEDIATE ROBUST ANTI-TUMOR ACTIVITY AGAINST GLIOBLASTOMA

被引：1
|
作者：
Miller, Jeffrey [1 ]
Cichocki, Frank [1 ]
Ning, Jianfang [1 ]
Bjordahl, Ryan [2 ]
Davis, Zachary [1 ]
Tuininga, Katie [1 ]
Wang, Hongbo [1 ]
Rogers, Paul [2 ]
Ge, Moyar [2 ]
Lee, Tom [2 ]
Valamehr, Bob [2 ]
Chen, Clark [2 ]
机构：
[1] Univ Minnesota, Minneapolis, MN USA
[2] Fate Therapeut Inc, San Diego, CA USA
来源：
JOURNAL FOR IMMUNOTHERAPY OF CANCER | 2020年 / 8卷
关键词：
D O I：
10.1136/jitc-2020-SITC2020.0155
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
155
引用
收藏
页码：A93 / A94
页数：2
相关论文
共 50 条
  • [1] iPSC-derived hypoimmunogenic tissue resident memory T cells mediate robust anti-tumor activity against cervical cancer
    Furukawa, Yoshiki
    Ishii, Midori
    Ando, Jun
    Ikeda, Kazuya
    Igarashi, Kyomi J.
    Kinoshita, Shintaro
    Azusawa, Yoko
    Toyota, Tokuko
    Honda, Tadahiro
    Nakanishi, Mahito
    Ohshima, Koichi
    Masuda, Ayako
    Yoshida, Emiko
    Kitade, Mari
    Porteus, Matthew
    Terao, Yasuhisa
    Nakauchi, Hiromitsu
    Ando, Miki
    CELL REPORTS MEDICINE, 2023, 4 (12)
  • [2] iPSC-Derived NK Cells Synergize with T Cells and Anti-PD-1 Antibody to Mediate Durable Anti-Tumor Responses In Vivo
    Miller, Jeffrey S.
    Bjordahl, Ryan
    Gaidarova, Svetlana
    Mahmood, Sajid
    Rogers, Paul
    Moyar, Ge
    Blazar, Bruce R.
    Kaufman, Dan S.
    Valamehr, Bahram
    Cichocki, Frank
    BLOOD, 2019, 134
  • [3] Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity
    Zhu, Huang
    Blum, Robert H.
    Bernareggi, Davide
    Ask, Eivind Heggernes
    Wu, Zhengming
    Hoel, Hanna Julie
    Meng, Zhipeng
    Wu, Chengsheng
    Guan, Kun-Liang
    Malmberg, Karl-Johan
    Kaufman, Dan S.
    CELL STEM CELL, 2020, 27 (02) : 224 - +
  • [4] IPSC-DERIVED NK CELLS EXHIBIT POTENT IN VITRO AND IN VIVO TUMORCIDAL ACTIVITY AGAINST PATIENTDERIVED GLIOBLASTOMA STEM CELLS (GSCS)
    Ning, Jianfang
    Davis, Zachary
    Cichocki, Frank
    Wang, Hongbo
    Tuininga, Katie
    Bjordahl, Ryan
    Lee, Tom
    Miller, Jeffrey
    Chen, Clark
    NEURO-ONCOLOGY, 2022, 24 : 224 - 224
  • [5] IPSC-Derived NK cells Exhibit Potent In Vitro and In Vivo Tumorcidal Activity Against Patient-Derived Glioblastoma Stem Cells (GSCs)
    Ning, Jianfang
    Davis, Zachary
    Cichocki, Frank
    Wang, Hongbo
    Tuininga, Katie
    Bjordahl, Ryan
    Lee, Tom
    Miller, Jeffrey
    Chen, Clark C. C.
    NEUROSURGERY, 2023, 69 : 87 - 88
  • [6] Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity
    Li, Ye
    Hermanson, David L.
    Moriarity, Branden S.
    Kaufman, Dan S.
    CELL STEM CELL, 2018, 23 (02) : 181 - +
  • [7] OFF-THE-SHELF, ENGINEERED IPSC-DERIVED NK CELLS MEDIATE POTENT CYTOTOXIC ACTIVITY AGAINST PRIMARY GLIOBLASTOMA CELLS AND PROMOTE DURABLE LONG-TERM SURVIVAL IN VIVO
    Cichocki, Frank
    Ning, Jianfang
    Davis, Zachary
    Wang, Hongbo
    Tuininga, Katie
    Bjordahl, Ryan
    Rogers, Paul
    Ge, Moyar
    Lee, Tom
    Valamehr, Bob
    Chen, Clark
    Miller, Jeffrey
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 : A180 - A180
  • [8] Leveraging CD16 fusion receptors to remodel the immune response for enhancing anti-tumor immunotherapy in iPSC-derived NK cells
    Fanyi Meng
    Siqi Zhang
    Juan Xie
    Yuan Zhou
    Qingling Wu
    Binyan Lu
    Shixin Zhou
    Xiangyu Zhao
    Yang Li
    Journal of Hematology & Oncology, 16
  • [9] Leveraging CD16 fusion receptors to remodel the immune response for enhancing anti-tumor immunotherapy in iPSC-derived NK cells
    Meng, Fanyi
    Zhang, Siqi
    Xie, Juan
    Zhou, Yuan
    Wu, Qingling
    Lu, Binyan
    Zhou, Shixin
    Zhao, Xiangyu
    Li, Yang
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2023, 16 (01)
  • [10] Development of Chimeric Antigen Receptor-Expressing iPSC-Derived Macrophages with Improved Anti-Tumor Activity
    Pouyanfard, Somayeh
    Fierro, Manuel
    Skaufman, Dan
    BLOOD, 2021, 138
12345