Isolation and structures of haterumadioxins A and B, cytotoxic endoperoxides from the Okinawan sponge Plakortis lita

被引：28

作者：

Takada, N

Watanabe, M

Yamada, A

Suenaga, K

Yamada, K

Ueda, K

Uemura, D ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Sci, Dept Chem, Chikusa Ku, Nagoya, Aichi 4648602, Japan

[2] Univ Ryukyus, Dept Chem Biol & Marine Sci, Okinawa 9030213, Japan

[3] Sagami Chem Res Ctr, Sagamihara, Kanagawa 2290012, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 03期

关键词：

D O I：

10.1021/np0003490

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Cytotoxic endoperoxides, haterumadioxins A (1) and B (2), were isolated from the Okinawan sponge Plakortis lita. Their structures were determined by spectroscopic analysis. The absolute stereostructure of 1 was determined by degradation reactions and the modified Mosher's method. Haterumadioxins showed significant cytotoxicity against 38 human cancer cell lines.

引用

页码：356 / 359

页数：4

共 50 条

[1] THE STRUCTURES AND CYTOTOXIC PROPERTIES OF POLYKETIDE PEROXIDES FROM A PLAKORTIS SPONGE
VAROGLU, M
PETERS, BM
CREWS, P
JOURNAL OF NATURAL PRODUCTS-LLOYDIA, 1995, 58 (01): : 27 - 36
[2] PEROXY ALIPHATIC ESTERS FROM THE SPONGE PLAKORTIS-LITA
DEGUZMAN, FS
SCHMITZ, FJ
JOURNAL OF NATURAL PRODUCTS, 1990, 53 (04): : 926 - 931
[3] ANTITUMOR CYCLIC PEROXIDES FROM THE SPONGE PLAKORTIS-LITA
SAKEMI, S
HIGA, T
ANTHONI, U
CHRISTOPHERSEN, C
TETRAHEDRON, 1987, 43 (01) : 263 - 268
[4] PLAKOTENIN, A NEW CYTOTOXIC CARBOXYLIC-ACID FROM THE OKINAWAN MARINE SPONGE PLAKORTIS-SP
KOBAYASHI, J
TAKEUCHI, S
ISHIBASHI, M
SHIGEMORI, H
SASAKI, T
TETRAHEDRON LETTERS, 1992, 33 (18) : 2579 - 2580
[5] Manadodioxans A−E: polyketide endoperoxides from the marine sponge Plakortis bergquistae
Masaki Gushiken
Ippei Kagiyama
Hikaru Kato
Toshiyuki Kuwana
Fitje Losung
Remy E. P. Mangindaan
Nicole J. de Voogd
Sachiko Tsukamoto
Journal of Natural Medicines, 2015, 69 : 595 - 600
[6] PLAKORTOLIDE, A CYTOTOXIC PEROXYLACTONE FROM A PLAKORTIS SPONGE
DAVIDSON, BS
TETRAHEDRON LETTERS, 1991, 32 (49) : 7167 - 7170
[7] ANTIFUNGAL PEROXYKETAL ACIDS FROM AN OKINAWAN MARINE SPONGE OF PLAKORTIS SP
KOBAYASHI, M
KONDO, K
KITAGAWA, I
CHEMICAL & PHARMACEUTICAL BULLETIN, 1993, 41 (07) : 1324 - 1326
[8] Cyclic polyketide peroxides and acyclic diol analogues from the sponge Plakortis lita
Harrison, B
Crews, P
JOURNAL OF NATURAL PRODUCTS, 1998, 61 (08): : 1033 - 1037
[9] Three new oxylipins from an Okinawan marine sponge Plakortis sp.
Tanaka, Naonobu
Asai, Miki
Kusama, Taishi
Fromont, Jane
Kobayashi, Jun'ichi
TETRAHEDRON LETTERS, 2015, 56 (11) : 1388 - 1391
[10] Manadodioxans A-E: polyketide endoperoxides from the marine sponge Plakortis bergquistae
Gushiken, Masaki
Kagiyama, Ippei
Kato, Hikaru
Kuwana, Toshiyuki
Losung, Fitje
Mangindaan, Remy E. P.
de Voogd, Nicole J.
Tsukamoto, Sachiko
JOURNAL OF NATURAL MEDICINES, 2015, 69 (04) : 595 - 600

← 1 2 3 4 5 →