Recent advances in cytoplasmic lipid droplet metabolism in intestinal enterocyte

被引：9

作者：

Ghanem, Murooj ^{[1
]}

Lewis, Gary F. ^{[2
,4
]}

Xiao, Changting ^{[1
,3
]}

机构：

[1] Univ Saskatchewan, Coll Med, Dept Anat Physiol & Pharmacol, Saskatoon, SK, Canada

[2] Univ Toronto, Dept Med & Physiol, Toronto, ON, Canada

[3] Univ Saskatchewan, Coll Med, Dept Anat Physiol & Pharmacol, 107 Wiggins Rd, Saskatoon, SK, Canada

[4] Univ Hlth Network, Toronto, ON, Canada

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2022年 / 1867卷 / 10期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Intestine; Triacylglycerol; Cytoplasmic lipid droplet; Enterocyte; HORMONE-SENSITIVE LIPASE; ADIPOSE TRIGLYCERIDE LIPASE; DIET-INDUCED OBESITY; FAT-ABSORPTION; PROTECTS MICE; ANIMAL-MODEL; ACYL-COA; TARGETED DISRUPTION; INSULIN-RESISTANCE; CHOLESTERYL ESTER;

D O I：

10.1016/j.bbalip.2022.159197

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Processing of dietary fats in the intestine is a highly regulated process that influences whole-body energy ho-meostasis and multiple physiological functions. Dysregulated lipid handling in the intestine leads to dyslipidemia and atherosclerotic cardiovascular disease. In intestinal enterocytes, lipids are incorporated into lipoproteins and cytoplasmic lipid droplets (CLDs). Lipoprotein synthesis and CLD metabolism are inter-connected pathways with multiple points of regulation. This review aims to highlight recent advances in the regulatory mechanisms of lipid processing in the enterocyte, with particular focus on CLDs. In-depth understanding of the regulation of lipid metabolism in the enterocyte may help identify therapeutic targets for the treatment and prevention of metabolic disorders.

引用

页数：11

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