Asymmetric organocatalytic N-nitroso-aldol reaction of oxindoles

被引：54
|
作者：
Zhang, Tao [1 ]
Cheng, Liang [1 ]
Liu, Li [1 ]
Wang, Dong [1 ]
Chen, Yong-Jun [1 ]
机构：
[1] Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, BNLMS, Beijing 100190, Peoples R China
来源：
TETRAHEDRON-ASYMMETRY | 2010年 / 21卷 / 23期
基金：
中国国家自然科学基金;
关键词：
ENANTIOSELECTIVE ALPHA-AMINOXYLATION; CONJUGATE ADDITION; ORGANIC CATALYSTS; ALDEHYDES; PROLINE; OXIDATION; KETONES; HYDROXYAMINATION; AMINOOXYLATION; SULFONAMIDE;
D O I：
10.1016/j.tetasy.2010.11.002
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
An organocatalytic enantioselective N-nitroso-aldol reaction of 2-oxindoles promoted by a cinchona alkaloid catalyst has been developed. The reaction shows exclusively N-selectivity, affording corresponding products with good to excellent yields (up to 100%) and moderate enantioselectivity. The regioselectivity of nitroso-aldol reaction being controlled by different cinchona catalysts was also observed. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2800 / 2806
页数：7
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