1,3-Thiazino[6,5-b]indol-4-one derivatives.: The first synthesis of indole phytoalexin cyclobrassinon

被引：9
|
作者：
Suchy, M
Kutschy, P
Dzurilla, M
Kovácik, V
Andreani, A
Alföldi, J
机构：
[1] Safarik Univ, Dept Organ Chem, Kosice 04167, Slovakia
[2] Slovak Acad Sci, Inst Chem, Bratislava 84238, Slovakia
[3] Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy
来源：
TETRAHEDRON LETTERS | 2001年 / 42卷 / 39期
关键词：
D O I：
10.1016/S0040-4039(01)01422-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first synthesis of indole phytoalexin cyclobrassinon in six steps, in 12% overall yield and some of its analogues, possessing a 1,3-thiazino[6,5-b]indol-4-one tricyclic ring system was performed, starting from 2-chloroindole-3-carboxaldehyde and employing the intramolecular Et3N-mediated nucleophilic substitution of a chlorine atom in the 2-position of an indole ring with sulfur as a key step. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：6961 / 6963
页数：3
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