Progress in the development of therapeutic antibodies targeting prion proteins and β-amyloid peptides

被引：3

作者：

He JinSheng ^{[1
]}

Zhang Ying ^{[1
]}

Hong Tao ^{[1
,2
]}

机构：

[1] Beijing Jiaotong Univ, Sch Sci, Coll Life Sci & Bioengn, Beijing 100044, Peoples R China

[2] Chinese Ctr Dis Control & Prevent, Inst Viral Dis Control & Prevent, Beijing 100052, Peoples R China

来源：

SCIENCE CHINA-LIFE SCIENCES | 2010年 / 53卷 / 08期

基金：

国家高技术研究发展计划(863计划);

关键词：

prion; Alzheimer's disease; immunotherapy; antibody; conformation; ANTI-PRP ANTIBODIES; MONOCLONAL-ANTIBODIES; A-BETA; ANTIIDIOTYPIC ANTIBODIES; ALZHEIMERS-DISEASE; CELL-LINES; EPITOPE; CONFORMATION; OLIGOMERS; FRAGMENT;

D O I：

10.1007/s11427-010-4043-z

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Prion diseases and Alzheimer's disease (AD) are characterized by protein misfolding, and can lead to dementia. However, prion diseases are infectious and transmissible, while AD is not. The similarities and differences between these diseases have led researchers to perform comparative studies. In the last 2 decades, progress has been made in immunotherapy using anti-prion protein and anti-beta-amyloid antibodies. In this study, we review new ideas and strategies for therapeutic antibodies targeting prion diseases and AD through conformation dependence.

引用

页码：959 / 963

页数：5

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