Study EV-302: A two-arm, open-label, randomized controlled phase 3 study of enfortumab vedotin in combination with pembrolizumab versus chemotherapy in previously untreated advanced urothelial carcinoma (aUC) (trial in progress).

被引:12
|
作者
Van der Heijden, Michiel Simon
Gupta, Shilpa
Galsky, Matt D.
Derleth, Christina Louise
Lee, Sue
Kataria, Ritesh S.
Powles, Thomas
机构
[1] Netherlands Canc Inst, Amsterdam, Netherlands
[2] Cleveland Clin Fdn, Taussig Canc Inst, Cleveland, OH USA
[3] Icahn Sch Med Mt Sinai, Tisch Canc Inst, Div Hematol & Med Oncol, New York, NY USA
[4] Seagen Inc, Bothell, WA USA
[5] Astellas Pharma Inc, Northbrook, IL USA
[6] Merck & Co Inc, Kenilworth, NJ USA
[7] Queen Mary Univ London, Barts Canc Inst, Canc Res UK Expt Canc Med Ctr, London, England
关键词
D O I
10.1200/JCO.2022.40.6_suppl.TPS589
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
TPS589
引用
收藏
页数:3
相关论文
共 50 条
  • [41] EV-202: An open-label, multicenter, phase 2 study of enfortumab vedotin in patients with previously treated locally advanced or metastatic solid tumors, including multiple gastroesophageal cancer cohorts
    Muro, K.
    Bruce, J. Yang
    Baranda, J.
    Campbell, M.
    Wu, C.
    Gorla, S.
    Braiteh, F.
    ANNALS OF ONCOLOGY, 2022, 33 : S298 - S298
  • [42] Tislelizumab Versus Docetaxel in Patients With Previously Treated Advanced NSCLC (RATIONALE-303): A Phase 3, Open-Label, Randomized Controlled Trial
    Zhou, Caicun
    Huang, Dingzhi
    Fan, Yun
    Yu, Xinmin
    Liu, Yunpeng
    Shu, Yongqian
    Ma, Zhiyong
    Wang, Ziping
    Cheng, Ying
    Wang, Jie
    Hu, Sheng
    Liu, Zhihua
    Poddubskaya, Elena
    Disel, Umut
    Akopov, Andrey
    Dvorkin, Mikhail
    Zheng, Wenjuan
    Ma, Yiyuan
    Wang, Yan
    Li, Songzi
    Yu, Cunjing
    Rivalland, Gareth
    JOURNAL OF THORACIC ONCOLOGY, 2023, 18 (01) : 93 - 105
  • [43] An open-label, randomized, Phase III Study of Nivolumab in Combination with Ipilimumab or with Standard Chemotherapy versus Standard Chemotherapy in Patients with previously untreated inoperable or metastatic Urothelial Carcinoma (CheckMate-901) - AB 59/17 of the AUO First-line Therapy for untreated, non-resectable or metastatic Urothelial Carcinoma
    Rexer, H.
    Retz, M.
    Waller, C.
    UROLOGE, 2018, 57 (07): : 880 - 881
  • [44] Open-label, randomized, phase 3 study of first-line lenvatinib plus pembrolizumab plus chemotherapy in esophageal squamous cell carcinoma: LEAP-014 trial in progress
    Sun, J.
    Enzinger, P.
    Adenis, A.
    Shah, M.
    Kato, K.
    Bennouna, J.
    Doi, T.
    Hawk, N.
    Yu, L.
    Shah, S.
    Bhagia, P.
    Shen, L.
    ANNALS OF ONCOLOGY, 2022, 33 : S352 - S352
  • [45] Camrelizumab in combination with preoperative chemotherapy for locally advanced esophageal squamous cell carcinoma: A single-arm, open-label, phase II study
    Wang Feng
    Qi Yu
    Meng Xiangrui
    Fan Qingxia
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (03)
  • [46] Pembrolizumab versus paclitaxel for previously treated advanced gastric or gastroesophageal junction cancer (KEYNOTE-063): A randomized, open-label, phase 3 trial in Asian patients
    Chung, Hyun Cheol
    Kang, Yoon-Koo
    Chen, Zhendong
    Bai, Yuxian
    Ishak, Wan Zamaniah Wan
    Shim, Byoung Yong
    Park, Young Lee
    Koo, Dong-Hoe
    Lu, Jianwei
    Xu, Jianming
    Chon, Hong Jae
    Bai, Li-Yuan
    Zeng, Shan
    Yuan, Ying
    Chen, Yen-Yang
    Gu, Kangsheng
    Zhong, Wen Yan
    Kuang, Shu
    Shih, Chie-Schin
    Qin, Shu-Kui
    CANCER, 2022, 128 (05) : 995 - 1003
  • [47] Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or metastatic non-small-cell lung cancer (KEYNOTE-042): a randomised, open-label, controlled, phase 3 trial
    Mok, Tony S. K.
    Wu, Yi-Long
    Kudaba, Iveta
    Kowalski, Dariusz M.
    Cho, Byoung Chul
    Turna, Hande Z.
    Castro, Gilberto, Jr.
    Srimuninnimit, Vichien
    Laktionov, Konstantin K.
    Bondarenko, Igor
    Kubota, Kaoru
    Lubiniecki, Gregory M.
    Zhang, Jin
    Kush, Debra
    Lopes, Gilberto
    LANCET, 2019, 393 (10183): : 1819 - 1830
  • [48] Trial in progress: A phase III, randomized, open-label study comparing zanubrutinib plus rituximab versus bendamustine plus rituximab in patients with previously untreated mantle cell lymphoma (MCL).
    Dreyling, martin H.
    Tam, Constantine Si Lun
    Wang, Michael
    Smith, Stephen Douglas
    Ladetto, Marco
    Huang, Huiqiang
    Elstrom, Rebecca L.
    Co, Melannie
    Holmgren, Eric
    Huang, Jane
    Gouill, Steven Le
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
  • [49] A phase 3, open-label, randomized study of nivolumab plus ipilimumab or standard of care (SOC) versus SOC alone in patients (pts) with previously untreated unresectable or metastatic urothelial carcinoma (mUC; CheckMate 901).
    Galsky, Matt D.
    Powles, Thomas
    Li, Shengting
    Hennicken, Delphine
    Sonpavde, Guru
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (06)
  • [50] Durvalumab alone and durvalumab plus tremelimumab versus chemotherapy in previously untreated patients with unresectable, locally advanced or metastatic urothelial carcinoma (DANUBE): a randomised, open-label, multicentre, phase 3 trial (vol 21, pg 1574, 2020)
    Powles, T.
    van der Heijden, M. S.
    Castellano, D.
    LANCET ONCOLOGY, 2021, 22 (01): : E5 - E5