Pharmacology and Therapeutic Potential of the 5-HT7 Receptor

被引：35
|
作者：
Blattner, Kevin M. [1 ]
Canney, Daniel J. [1 ]
Pippin, Douglas A. [2 ]
Blass, Benjamin E. [1 ]
机构：
[1] Temple Univ, Sch Pharm, Dept Pharmaceut Sci, Moulder Ctr Drug Discovery Res, 3307 North Broad St, Philadelphia, PA 19140 USA
[2] Praeventix LLC, 665 Stockton Dr,Suite 200H, Exton, PA 19341 USA
来源：
ACS CHEMICAL NEUROSCIENCE | 2019年 / 10卷 / 01期
关键词：
Serotonin receptor; serotonin (5-HT); G-protein-coupled receptor (GPCR); 5-HT7; receptor; agonist; antagonist; PROTEIN-KINASE-A; EXTRACELLULAR-REGULATED KINASE; ANTEROVENTRAL PREOPTIC REGION; ANTIDEPRESSANT-LIKE BEHAVIOR; MULTIOBJECTIVE BASED DESIGN; PHRENIC MOTOR FACILITATION; DEPRESSIVE-LIKE BEHAVIORS; GENOME-WIDE ASSOCIATION; BETA-CASEIN EXPRESSION; EYE-MOVEMENT SLEEP;
D O I：
10.1021/acschemneuro.8b00283
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
It is well-documented that serotonin (5-HT) exerts its pharmacological effects through a series of 5-HT receptors. The most recently identified member of this family, 5-HT7, was first identified in 1993. Over the course of the last 25 years, this receptor has been the subject of intense investigation, and it has been demonstrated that 5-HT7 plays an important role in a wide range of pharmacological processes. As a result of these findings, modulation of 5-HT7 activity has been the focus of numerous drug discovery and development programs. This review provides an overview of the roles of 5-HT7 in normal physiology and the therapeutic potential of this interesting drug target.
引用
收藏
页码：89 / 119
页数：61
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