Safety and Efficacy of Venetoclax (VEN) in Combination with Bendamustine (B) Plus Rituximab (R) or Obinutuzumab (G) in Patients (pts) with Previously Untreated Chronic Lymphocytic Leukemia (CLL): Results from a Phase Ib Study (GO28440)

被引:0
|
作者
Stilgenbauer, Stephan [1 ]
Morschhauser, Franck [2 ]
Wendtner, Clemens-Martin [3 ]
Cartron, Guillaume [4 ]
Hallek, Michael [5 ,6 ]
Eichhorst, Barbara [7 ]
Kozloff, Mark F. [8 ]
Giever, Thomas [9 ]
Lozanski, Gerard [10 ]
Jiang, Yanwen [11 ]
Huang, Huang [12 ]
Pignataro, Daniela Soriano [13 ]
Schary, William [14 ]
Humphrey, Kathryn [15 ]
Mobasher, Mehrdad [11 ]
Salles, Gilles [16 ]
机构
[1] Ulm Univ, Dept Internal Med 3, Ulm, Germany
[2] Univ Lille 2, Ctr Hosp Univ, Hematol, Lille, France
[3] Klinikum Schwabing, Dept Hematol Oncol Immunol Palliat Care Infect Di, Munich, Germany
[4] Univ Hosp Montpellier, Dept Clin Hematol, Montpellier, France
[5] Univ Hosp Cologne, Dept Internal Med 1, Cologne, Germany
[6] Univ Hosp Cologne, Ctr Integrated Oncol Cologne Bonn, German CLL Study Grp, Cologne, Germany
[7] Univ Cologne, Dept Internal Med 1, Cologne, Germany
[8] Univ Chicago Med, Chicago, IL USA
[9] Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA
[10] Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA
[11] Genentech Inc, San Francisco, CA 94080 USA
[12] F Hoffmann La Roche Ltd, Mississauga, ON, Canada
[13] Roche Prod Ltd, Welwyn Garden City, Herts, England
[14] AbbVie, N Chicago, IL USA
[15] Roche Prod Ltd, Welwyn Garden City, Herts, England
[16] Univ Claude Bernard Lyon 1, Hosp Civils Lyon, CHU Lyon Sud, Dept Hematol, Pierre Benite, France
关键词
D O I
10.1182/blood-2018-99-118362
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1859
引用
收藏
页数:5
相关论文
共 50 条
  • [31] Preliminary Safety Results from the Phase IIIb GREEN Study of Obinutuzumab (GA101) Alone or in Combination with Chemotherapy for Previously Untreated or Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL)
    Bosch, Francesc
    Illmer, Thomas
    Turgut, Mehmet
    Cortelezzi, Agostino
    Lasserre, Susan F.
    Truppel-Hartmann, Anna
    Leblond, Veronique
    Foa, Robin
    Stilgenbauer, Stephan
    BLOOD, 2014, 124 (21)
  • [32] Bendamustine, followed by obinutuzumab, acalabrutinib and venetoclax in patients (Pts) with relapsed/refractory chronic lymphocytic Leukemia (CLL): updated results of the CLL2-BAAG trial of the German CLL Study Group (GCLLSG)
    Cramer, Paula
    Fuerstenau, Moritz
    Robrecht, Sandra
    Giza, Adam
    Fink, Anna
    Fischer, Kirsten
    Langerbeins, Petra
    Al-Sawaf, Othman
    Tausch, Eugen
    Schneider, Christof
    Schetelig, Johannes
    Dreger, Peter
    Boettcher, Sebastian
    Kreuzer, Karl-Anton
    Schilhabel, Anke
    Brueggemann, Monika
    Kneba, Michael
    Wendtner, Clemens
    Stilgenbauer, Stephan
    Eichhorst, Barbara
    Hallek, Michael
    LEUKEMIA & LYMPHOMA, 2023, 64 : S18 - S19
  • [33] Improvements in Health-Related Quality of Life and Symptoms in Patients with Previously Untreated Chronic Lymphocytic Leukemia: Final Results from the Phase II GIBB Study of the Combination of Obinutuzumab and Bendamustine
    Danilov, Alexey
    Yimer, Habte A.
    Boxer, Michael
    Burke, John M.
    Babu, Sunil
    Li, Jia
    Mun, Yong
    Trask, Peter C.
    Masaquel, Anthony S.
    Sharman, Jeff P.
    BLOOD, 2019, 134
  • [34] Genomic Alterations and Outcomes With Fixed-Duration Ibrutinib plus Venetoclax: Results From the Phase 3 GLOW Study in Patients With Previously Untreated Chronic Lymphocytic Leukemia (CLL)
    Kater, Arnon
    Hodkinson, Brendan
    Moreno, Carol
    Munir, Talha
    Levin, Mark-David
    Niemann, Carsten
    Qi, Keqin
    Sinet, Pierre
    Baeten, Kurt
    Caces, Donne Bennett
    Srinivasan, Srimathi
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2023, 23 : S329 - S329
  • [35] Improvements in Health-related Quality of Life and Symptoms in Patients With Previously Untreated Chronic Lymphocytic Leukemia: Final Results From the Phase II GIBB Study of the Combination of Obinutuzumab and Bendamustine
    Danilov, Alexey, V
    Yimer, Habte A.
    Boxer, Michael A.
    Burke, John M.
    Babu, Sunil
    Li, Jia
    Mun, Yong
    Trask, Peter C.
    Masaquel, Anthony S.
    Sharman, Jeff P.
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2022, 22 (02): : 121 - 128
  • [36] A041702: A Randomized Phase III Study of Ibrutinib Plus Obinutuzumab Versus Ibrutinib Plus Venetoclax and Obinutuzumab in Untreated Older Patients (≥ 70 Years of Age) with Chronic Lymphocytic Leukemia (CLL)
    Woyach, Jennifer A.
    Ruppert, Amy S.
    Perez, Gabriela
    Booth, Allison M.
    Feldman, Diane
    Dib, Elie G.
    Jatoi, Aminah
    Le-Rademacher, Jennifer
    Heerema, Nyla A.
    Miller, Cecelia
    Lozanski, Gerard
    Little, Richard F.
    Hill, Brian T.
    Ding, Wei
    Stone, Richard M.
    Mandrekar, Sumithra J.
    Byrd, John C.
    BLOOD, 2021, 138 : 3728 - +
  • [37] Obinutuzumab Alone or Combined with Chemotherapy in Previously Untreated (Fit or Unfit) or Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL) Patients: Final Results from the Phase IIIb GREEN Safety Study with a Focus on Efficacy
    Stilgenbauer, Stephan
    Bosch, Francesc
    Leblond, Veronique
    Ilhan, Osman
    Kisro, Jens
    Mahe, Beatrice
    Mikuskova, Eva
    Osmanov, Dzhelil
    Reda, Gianluigi
    Tausch, Eugen
    Wojtowicz, Marcin
    Perretti, Thomas
    Van Hoef, Marlies E. H. M.
    Foa, Robin
    BLOOD, 2019, 134
  • [39] PRELIMINARY SAFETY DATA FROM THE PHASE 3B GREEN STUDY OF OBINUTUZUMAB (G) ALONE OR COMBINED WITH CHEMOTHERAPY FOR PREVIOUSLY UNTREATED OR RELAPSED/REFRACTORY CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)
    Leblond, V.
    Dilhuydy, M. S.
    Foa, R.
    Knauf, W.
    Montillo, M.
    Robinson, S.
    Stilgenbauer, S.
    Gresko, E.
    Lasserre, S.
    Bosch, F.
    HAEMATOLOGICA, 2016, 101 : 149 - 149
  • [40] Updated Safety and Preliminary Efficacy Data from a Phase 1b Study Combining Venetoclax (GDC-0199, ABT-199) with Bendamustine/Rituximab in Patients with Relapsed/Refractory or Previously Untreated Chronic Lymphocytic Leukemia
    Salles, Gilles A.
    Boyd, Thomas E.
    Morschhauser, Franck
    Wendtner, Clemens-Martin
    Hallek, Michael
    Eichhorst, Barbara F.
    Kozloff, Mark
    Cartron, Guillaume
    Li, Yan
    Hilger, James
    Mobasher, Mehrdad
    Stilgenbauer, Stephan
    BLOOD, 2015, 126 (23)