Catalyst-Controlled Regioselective Synthesis of Benzotriazlolodiazepin-7-ones and Benzotriazolodiazocin-8-ones

被引：12

作者：

Chen, Kai-Chi ^{[1
]}

Barve, Indrajeet J. ^{[1
,2
]}

Sun, Chung-Ming ^{[1
,3
]}

机构：

[1] Natl Chiao Tung Univ, Dept Appl Chem, 1001 Ta Hsueh Rd, Hsinchu 30010, Taiwan

[2] Kaohsiung Med Univ, Dept Med & Appl Chem, 100 Shih Chuan First Rd, Kaohsiung 80708, Taiwan

[3] MES Abasaheb Garware Coll, Dept Chem, Pune, Maharashtra, India

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 02期

关键词：

CYCLIZATION; EFFICIENT; CONSTRUCTION; EXPANSION; PEPTIDES; STRATEGY; INSOMNIA; LACTAMS; ALKYNES; ENTRY;

D O I：

10.1021/acs.orglett.9b04162

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A catalyst-controlled highly chemoselective and regioselective intramolecular cycloamidation of triazol-1-ylbenzamides toward the synthesis of scarcely known heterocycles is reported. In the presence of a palladium catalyst, this cycloisomerization reaction afforded substituted benzotriazlolodiazepin-7-ones via intramolecular insertion of a palladium into C-C triple bond in a 7-exo-dig way. Alternatively, the use of a silver catalyst in the reaction produced substituted benzotriazolodiazocin-8-ones in a highly regioselective manner through 8-endo-dig intramolecular ring closure.

引用

页码：428 / 432

页数：5

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