Tularaemia outbreaks in Sakarya, Turkey: case-control and environmental studies

被引:0
|
作者
Meric, M. [1 ]
Sayan, M. [2 ]
Dundar, D. [3 ]
Willke, A. [1 ]
机构
[1] Kocaeli Univ, Fac Med, Dept Clin Bacteriol & Infect Dis, TR-41380 Umuttepe Kocaeli, Turkey
[2] Kocaeli Univ, PCR Unit, Climatol Lab, TR-41380 Umuttepe Kocaeli, Turkey
[3] Kocaeli Univ, Dept Microbiol, TR-41380 Umuttepe Kocaeli, Turkey
关键词
Francisella tularensis; outbreaks; polymerase chain reaction; risk factors; tularaemia;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Tularaemia is an important zoonotic disease that leads to outbreaks. This study aimed to compare the epidemiological characteristics of two tularaemia outbreaks that occurred in the Sakarya region of Turkey, analyse the risk factors for the development of outbreaks and identify Francisella (F.) tularensis in the water samples. Methods: Two tularaemia outbreaks occurred in the Kocadongel village in 2005 and 2006. A field investigation and a case-control study with 47 cases and 47 healthy households were performed during the second outbreak. Clinical samples from the patients and filtrated water samples were analysed for F. tularensis via real-time polymerase chain reaction. Results: From the two outbreaks, a total of 58 patients were diagnosed with oropharyngeal tularaemia based on their clinical and serological results. Both outbreaks occurred between the months of January and April, and the number of patients peaked in February. Logistic regression analysis revealed that the consumption of natural spring water was the only significant risk factor for tularaemia infection (odds ratio 3.5, confidence interval 1.23-10.07). F. tularensis was detected in eight clinical samples and in the filtrated natural spring water. Conclusion: This study is the first report of tularaemia from this region. The results show that both tularaemia outbreaks were related to the consumption of untreated natural spring water. To prevent waterborne tularaemia, community water supplies should be treated and checked periodically.
引用
收藏
页码:655 / 659
页数:5
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