An In Vitro Model of Triple-Negative Breast Cancer

被引：1
|
作者：
Russo, J. [1 ]
Su, Y. [1 ]
机构：
[1] Fox Chase Canc Ctr Temple Hlth, Breast Canc Res Lab, Philadelphia, PA 19111 USA
来源：
HUMAN CELL TRANSFORMATION: ADVANCES IN CELL MODELS FOR THE STUDY OF CANCER AND AGING | 2019年 / 1164卷
关键词：
17; beta-estradiol; Human breast epithelial cells; Epithelial to mesenchymal transition; Triple-negative breast cancer; Chromatin remodeling; Breast epithelial cell transformation; EPITHELIAL-MESENCHYMAL TRANSITION; ADHESION MOLECULE ANTIBODIES; NEOPLASTIC TRANSFORMATION; CELL-LINES; ESTROGEN; 17-BETA-ESTRADIOL; IDENTIFICATION; METABOLITES; EXPRESSION; RECEPTORS;
D O I：
10.1007/978-3-030-22254-3_3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We have characterized two highly tumorigenic and metastatic basal B TNBC cell lines, XtMCF and LmMCF, with the additional values of having the normal and early-stage counterparts of them. This model allows the study of the evolution of TNBC, and investigates molecular pathways at different stages of transformation and progression in a relatively constant genetic background. This constitutes an ideal model for developing targeted therapy in two important fields in cancer biology which are the epithelial mesenchymal transition (EMT) and cancer stem cells (CSC).
引用
收藏
页码：35 / 46
页数：12
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