A one-pot three-step multicomponent synthesis of functionalized allyl dithiocarbamates using Baylis-Hillman reaction

被引：6
|
作者：
Ziyaei Halimehjani, Azim [1 ]
Lotfi Nosood, Yazdanbakhsh [1 ]
Sharifi, Marzieh [1 ]
机构：
[1] Kharazmi Univ, Fac Chem, Tehran 15614, Iran
来源：
SYNTHETIC COMMUNICATIONS | 2020年 / 50卷 / 07期
关键词：
Allyl dithiocarbamates; Baylis-Hillman reaction; carbon disulfide; multicomponent reactions; EFFICIENT; DERIVATIVES; ACCESS;
D O I：
10.1080/00397911.2020.1725974
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot, pseudo five-component, highly diastereoselective, and mild procedure for the synthesis of functionalized allyl dithiocarbamates is developed. The Baylis-Hillman (BH) reaction of aromatic (heteroaromatic) aldehydes and activated alkenes using DABCO, followed by acetylation of BH adducts with acetic anhydride in the presence of a catalytic amount of DMAP, and nucleophilic substitution reaction by in situ prepared dithiocarbamates from amines and CS2 are three steps of this protocol.
引用
收藏
页码：966 / 972
页数：7
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